• JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
 
  Bookmark and Share
 
 
Master's Dissertation
DOI
https://doi.org/10.11606/D.98.2022.tde-10072023-152852
Document
Author
Full name
Amanda Vanessa Demarchi
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2022
Supervisor
Committee
Armaganijan, Luciana Vidal (President)
Cintra, Fatima Dumas
Figueiredo, Marcio Jansen de Oliveira
Valdigem, Bruno Pereira
Title in Portuguese
Relação entre os escores CHADS2 e CHA2DS2-VASc e índices de onda P em pacientes sem fibrilação atrial e sem doença valvar
Keywords in Portuguese
Ecocardiografia
Eletrocardiografia
Fatores de risco
Onda P
Abstract in Portuguese
Introdução: Os escores CHADS2 e CHA2DS2-VASc são utilizados como preditores de desfecho cardiovascular mesmo na ausência de fibrilação atrial (FA). Diversos índices de onda P e parâmetros ecocardiográficos associam-se a maior risco de desenvolvimento de FA e tromboembolismo, entretanto, há poucos estudos em pacientes sem FA. Objetivos: Primário: avaliar a associação entre os índices de onda P (duração média, desvio padrão e variabilidade da onda P, duração da P máxima e P mínima, dispersão de onda P, voltagem de onda P em DI, índice de Morris, intervalo PR, relação P/PRi e tempo de ativação da onda P em DII) e escores CHADS2 e CHA2DS2-VASc em pacientes sem fibrilação atrial e sem doença valvar. Secundário: avaliar a associação entre parâmetros ecocardiográficos [tamanho de átrio esquerdo (AE) e ventrículo esquerdo (VE), fração de ejeção do VE (FEVE), massa do VE e massa indexada do VE] e escores CHADS2 e CHA2DS2-VASc na mesma população. Métodos: Estudo transversal, descritivo e analítico no qual dados clínicos, eletrocardiográficos e ecocardiográficos de 272 pacientes sem FA conhecida e sem doença valvar foram coletados e analisados. Os eletrocardiogramas foram digitalizados e as medidas foram realizadas com o programa CardioCalipers®. Para análise estatística, foram utilizados os testes do Qui-quadrado, t de Student, U de Mann-Whitney, teste exato de Fisher e Coeficiente de Spearman. O nível de significância de 5% foi adotado para todos os testes. Resultados: Tanto para escore CHADS2 quanto CHA2DS2-VASc, o intervalo PR, diâmetro de AE e de VE, massa do VE e massa indexada do VE associaram-se positivamente, enquanto amplitude de onda P, voltagem de onda P em D1 e FEVE apresentaram associação negativa. A duração média da onda P correlacionou-se positivamente com o escore CHADS2, enquanto a presença do sinal de Morris correlacionou-se com CHA2DS2-VASc alto. Conclusões: A associação entre índices de onda P, variáveis ecocardiográficas e escores CHADS2 e CHA2DS2-VASc pode ser útil na prática clínica para avaliar pacientes que tendem a ter maior risco cardiovascular utilizando-se parâmetros clínicos e métodos não invasivos. Este trabalho traz resultados sobre esta relação que carece de informações em pacientes sem FA.
Title in English
Relationship between CHADS2 and CHA2DS2-VASc scores and P-wave indexes in patients without atrial fibrillation and heart valve disease
Keywords in English
Echocardiography
Electrocardiography
P-wave
Risk Factors
Abstract in English
Introduction: The CHADS2 and CHA2DS2-VASc scores have been used as predictors of cardiovascular outcomes even in the absence of atrial fibrillation (AF). Several P wave indexes and echocardiographic parameters are associated with a higher risk of developing AF and thromboembolism, however, there are few studies in patients without AF. Objectives: Primary: Evaluate the association between P wave indexes [P wave duration, dispersion and variability, P maximum and P minimum duration, P wave voltage in lead I, Morris index, PR interval (PRi), P/PRi ratio and P wave peak time in lead II] and CHADS2 and CHA2DS2-VASc scores in patients without atrial fibrillation and without valve disease. Secondary: to evaluate the association between echocardiographic parameters [left atrium (LA) and left ventricle (LV) size, LV ejection fraction (LVEF), LV mass and LV indexed mass] and CHADS2 and CHA2DS2-VASc scores in the same population. Methods: A cross-sectional, descriptive and analytical study in which clinical, electrocardiographic and echocardiographic data from 272 patients without known AF and without valvular disease were collected and analyzed. Electrocardiograms were digitized and measurements were performed using the CardioCalipers® program. For statistical analysis, the Chi-Square test, t-Student test, Mann-Whitney U-test, Fisher's exact test and Spearman correlation were used, and the significance level of 5% was adopted for all tests. Results: PRi, LA and LV diameter, LV mass and LV indexed mass were positively associated with both CHADS2 and CHA2DS2-VASc scores, while P wave amplitude, P wave voltage in lead I and LVEF were negatively associated to the same scores. The P wave duration was positively associated with CHADS2 score and the presence of the Morris index was related with high CHA2DS2-VASc. Conclusions: The association between P wave indexes, echocardiographic variables and CHADS2 and CHA2DS2-VASc scores may be useful in clinical practice to evaluate patients who trend to have a higher cardiovascular risk using clinical parameters and non-invasive methods in patients without AF.
 
WARNING - Viewing this document is conditioned on your acceptance of the following terms of use:
This document is only for private use for research and teaching activities. Reproduction for commercial use is forbidden. This rights cover the whole data about this document as well as its contents. Any uses or copies of this document in whole or in part must include the author's name.
Publishing Date
2023-10-06
 
WARNING: Learn what derived works are clicking here.
All rights of the thesis/dissertation are from the authors
CeTI-SC/STI
Digital Library of Theses and Dissertations of USP. Copyright © 2001-2024. All rights reserved.