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Master's Dissertation
DOI
https://doi.org/10.11606/D.98.2021.tde-08022022-160237
Document
Author
Full name
Maita Pretti Nunes Ferreira
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2020
Supervisor
Committee
Armaganijan, Luciana Vidal (President)
Cintra, Fatima Dumas
Fernandes, Luciana Sacilotto
Moreira, Dalmo Antonio Ribeiro
Title in Portuguese
Correlação entre intervalo HV e achados eletrocardiográficos em indivíduos com síncope e bloqueio de ramo esquerdo
Keywords in Portuguese
Arritmias Cardíacas
Bloqueio de ramo esquerdo
Eletrocardiografia
Eletrofisiologia
Síncope
Abstract in Portuguese
Introdução: A ocorrência de síncope é relacionada a mortalidade em portadores de bloqueio de ramo esquerdo (BRE), mas estes representam um grupo heterogêneo de indivíduos. Dentre os escores de risco para síncope, é consenso que as anormalidades eletrocardiográficas e a presença de cardiopatia subjacente são fatores proeminentes. Porém, não existe aprofundamento direcionado a essa população e pouco há que se agregue ao julgamento clínico nesses casos, até que o estudo eletrofisiológico (EEF) seja feito. A sensibilidade módica do método torna seu emprego prático conflitante com a literatura. Deste modo, identificar os pacientes mais propensos a eventos graves é clinicamente significativo. Objetivos e métodos: Este foi um estudo transversal que incluiu pacientes com síncope e BRE submetidos a EEF em um hospital terciário especializado em Cardiologia, com o objetivo de avaliar a associação entre os parâmetros de eletrocardiograma (ECG) ao prolongamento do intervalo HV no EEF. Resultados: 94 pacientes consecutivos foram elegíveis para a análise final. A idade média foi de 63,1 ± 11,9 anos, com predomínio do gênero masculino (68,1%) na amostra. Quanto as principais comorbidades, a prevalência de tabagismo foi de 39,3%, hipertensão 84%, diabetes mellitus (DM) 29,7%, doença arterial coronária (DAC) 28,7% e fração de ejeção do ventrículo esquerdo (FEVE) reduzida ( 40%) 48,9%. Na análise univariada, FEVE 40% aparentou importância que não foi confirmada após regressão logística. Os valores de QRS médio 165 milissegundos (ms) (odds ratio [OR] 7,7 valor de p [p] < 0,001) e de intervalo PR 220ms (OR 7,10 p < 0,005) foram preditores independentes para intervalo HV 70ms. No subgrupo de pacientes com este desfecho, o QRS médio foi de 170,88 ± 26,81ms, significativamente maior do que no grupo controle. Outros dados analisados não foram sistematicamente associados ao desfecho. Conclusão: Em pacientes com síncope e BRE, a duração do QRS e a do intervalo PR foram preditores independentes de intervalo HV aumentado no EEF. Pesquisas em maior escala são necessárias para confirmação subsequente.
Title in English
Correlation between HV interval and electrocardiographic findings in individuals with syncope and left bundle branch blockage
Keywords in English
Cardiac arrhythmias
Electrocardiography
Electrophysiology
Left bundle branch blockage
Syncope
Abstract in English
Introduction: The occurrence of syncope is related to mortality in left bundle branch blockage (LBBB) patients, but these make up a heterogeneous group of individuals. Among syncope risk scores, it is consensual that electrocardiographic abnormalities and the presence of underlying cardiac disease are prominent factors. However, there is no further investigation directed towards this population and there is few that could add to clinical judgement in such cases, until electrophysiological study (EP study) is performed. The methods modest sensitivity limits its practical usage in spite of current literature recommendation. Therefore, identifying those patients more prone to serious events is of clinical significance. Objectives and methods: This was a cross-sectional study which included patients with syncope and LBBB submitted to EP study in a tertiary hospital specialized in Cardiology, with the goal to assess the relation between electrocardiogram [EKG] parameters and prolonged HV interval during EP study. Results: 94 consecutive patients were eligible for the final analysis. Mean age was 63.1 ± 11.9 years, with male majority (68.1%) in the sample. As for main comorbidities, the prevalence of smoking was 39.3%, hypertension 84%, diabetes mellitus (DM) 29.7%, coronary artery disease (CAD) 28.7% and reduced left ventricle ejection fraction (LVEF) ( 40%) 48.9%. In the univariate analysis, LVEF 40% appeared to be somewhat important but this was not confirmed upon logistic regression. Duration of mean QRS 165 milisseconds (ms) (odds ratio [OR] 7.79; p-value [p] < 0.001) and of PR interval 220ms (OR 7.10; p < 0.005) were independent predictors for HV interval 70ms. For the subgroup presented with such outcome, mean QRS was 170.88 ± 26.81ms, significantly larger than the control groups QRS. Other analyzed data were not systematically associated with the evaluated outcomes. Conclusion: In patients with syncope and LBBB, enlargement of QRS and PR interval were independent predictors for increased HV interval during EP study. Larger scale researches are needed for subsequent confirmation.
 
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Publishing Date
2022-05-16
 
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