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Master's Dissertation
DOI
10.11606/D.9.1998.tde-15042015-105032
Document
Author
Full name
Clarice Yakabe
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 1998
Supervisor
Committee
Martins, Jorge Luiz Seferin (President)
Magalhaes, Joao Fernandes
Oliveira Neto, Graciliano de
Title in Portuguese
Determinação espectrofotométrica da nimesulida em formulações farmacêuticas
Keywords in Portuguese
Medicamento
Química analítica instrumental
Abstract in Portuguese
Um método espectrofotométrico no visível, simples, rápido, exato, preciso e econômico foi desenvolvido para determinação da nimesulida nas formas farmacêuticas comprimido, suspensão, granulado e supositório. Solução de hidróxido de sódio 0,1 M foi utilizada como solvente. Nesta solução, a nimesulida desenvolveu coloração amarela estável à temperatura ambiente, obtendo-se um pico de absorção máximo em 393 nm. O método obedeceu a lei de Lambert-Beer na faixa de concentração de 7,0 a 16,0 µg/mL (R2 = 0,9999). Não houve interferência dos excipientes da formulação, e no intervalo de concentração de 25,0 a 125,0 mg, o método mostrou-se linear.
Title in English
Spectrophotometric determination of nimesulide in pharmaceutical formulations
Keywords in English
Instrumental analytical chemistry
Medicine
Abstract in English
A simple, fast, accurate, precise and economical visible spectrophotometric method for nimesulide determination in tablets, suspension, granulate and suppository was developed. Sodium hydroxide 0,1 M solution was used as solvent. In this solution nimesulide developed a yellow color which is stable at room temperature, presenting a maximum absorption at 393 nm. The method obeyed Lambert-Beer's law in a concentration range from 7,0 to 16,0 µg/mL (R2 =0,9999). The formulation's excipients did not interfere and in the range of concentration from 25,0 to 125,0 mg the method showed to be linear.
 
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Publishing Date
2015-04-15
 
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