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Doctoral Thesis
DOI
10.11606/T.9.1992.tde-06032015-154829
Document
Author
Full name
Silvia Storpirtis
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 1992
Supervisor
Committee
Santos, Silvia Regina Cavani Jorge (President)
Carvalho, Dermeval de
Magalhaes, Joao Fernandes
Oga, Seizi
Oliveira Neto, Graciliano de
Title in Portuguese
Alterações na depuração plasmática e na excreção renal de antipirina e seus produtos de biotransformação em pacientes portadores de hepatopatias
Keywords in Portuguese
Antipirina
Farmacocinética
Farmacologia
Fármacos (Metabolismo)
Medicamento
Abstract in Portuguese
Avaliaram-se as alterações na eliminação da antipirina e de seus principais produtos de biotransformação, 3-hidroximetilantipirina (3HMA), 4-hidroxiantipirina (4HOA) e norantipirina (NORA) em pacientes portadores de doenças hepáticas. Investigaram-se onze pacientes com cirrose hepática confirmada por biopsia, nove pacientes com esquistossomose hepatesplênica e vinte e cinco voluntários sadios. Os "clearancesn total e hepático da antipirina foram reduzidos com prolongamento de sua meiavida de eliminação nos pacientes cirróticos. Os "clearances" de formação da 3HMA, 4HOA e NORA também foram reduzidos como consequência de seu comprometimento hepático. Os pacientes com esquistossomose hepatesplênica mostraram alterações no metabolismo da antipirina, afetando os "clearances" de formação da 3HMA e da 4HOA, enquanto que para a NORA este parãmetro manteve-se inalterado. Deste modo, a determinação do "clearance" total da antipirina e da excreção urinária da antipirina e seus principais produtos de biotransformação mostrou ser teste útil para avaliar o metabolismo oxidativo nas doenças hepáticas.
Title in English
Changes in plasma clearance and renal excretion antipyrine and their biotransformation products in patients with liver diseases
Keywords in English
Antipyrine
Drug
Pharmacokinetics
Pharmacology
Abstract in English
Changes on elimination of antipyrine and its main metabolites, 3-hydroxymethylantipyrine (3HMA), 4hydroxyantipyrine (4HOA) and norantipyrine (NORA) in patients with liver disease were evaluated. Eleven patients with liver cirrhosis virus B, biopsy confirmed, nine patients with hepatesplenic shistosomiasis and twenty-five healthy volunteers were investigated. Total body clearance and hepatic clearance of antipyrine were reduced with prolongation of its elimination half-life in cirrhotic patients. Clearances for production of 3HMA, 4HOA and NORA were reduced as a consequence of this liver impairment. Patients with hepatesplenic shistosomiasis showed changes on antipyrine metabolism affecting only the clearance for production of 3HMA and 4HOA, while NORA was unchanged. Therefore, the determination of antipyrine plasma clearance and urinary excretion of antipyrine and its main metabolites showed to be a usefu
 
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Publishing Date
2015-03-06
 
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