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Master's Dissertation
DOI
10.11606/D.9.2002.tde-03052010-162703
Document
Author
Full name
Edimar Cristiano Pereira
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2002
Supervisor
Committee
Abdalla, Dulcineia Saes Parra (President)
Bertolami, Marcelo Chiara
Gomes, Ligia Ferreira
Title in Portuguese
Efeito da sinvastatina, alfa-tocoferol e L-arginina sobre os inibidores endógenos da óxido nítrico sintase, metabólitos do óxido nítrico e tióis em pacientes hipercolesterolêmicos
Keywords in Portuguese
alfa-tocoferol
Bioquímica
Hipercolesterolemia
Inibidores endógenos da óxido nítrico sintase
L-arginina
Metabólitos da óxido nítrico
Nitrogenase (Fisiologia)
Sinvastatina
Tióis
Abstract in Portuguese
O objetivo deste estudo foi avaliar o efeito da sinvastatina, isolada e associada ao α-tocoferol e à L-arginina, sobre os inibidores endógenos da óxido nítrico sintase, os metabólitos do óxido nítrico e tióis, em pacientes hipercolesterolêmicos. Analisou-se um grupo de 16 pacientes hipercolesterolêmicos que seguiram o seguinte protocolo: período de washout (sem medicação), 1 mês; sinvastatina (20mg/dia), 2 meses; sinvastatina (20mg/dia) + α-tocoferol (400U/dia), 2 meses; sinvastatina (20mg/dia, washout), 1 mês; sinvastatina (20mg/dia) + L-arginina (7g/dia), 2 meses. A sinvastatina reduziu significativamente as concentrações do colesterol total e LDL-colesterol e a razão LDL-colesterol/HDL-colesterol. O tratamento com sinvastatina, isolada e associada ao α-tocoferol, promoveu diminuição nas concentrações de S-nitrosotióis. A L-arginina associada à sinvastatina, aumentou os níveis de colesterol total quando comparada com a sinvastatina isoladamente. As concentrações plasmáticas de α-tocoferol e L-arginina não aumentaram em decorrência da suplementação, devido à grande dispersão dos dados obtidos, embora as medianas das concentrações plasmáticas de Larginina e α-tocoferol tenham sido mais elevadas após as suplementações. O tratamento com sinvastatina, isolada ou associada à L-arginina e ao α-tocoferol, não alterou as concentrações dos inibidores endógenos da óxido nítrico sintase (ADMA e SDMA), dos metabólitos do óxido nítrico, da nitrotirosina total e dos tióis analisados.
Title in English
Effect of simvastatin, alpha-tocopherol and L-arginin on the endogenous nitric oxide synthase inhibitors, nitric oxide metabolites and thiols in hypercholesterolemic patients
Keywords in English
alpha-tocopherol
Biochemistry
Endogenous nitric oxide synthase inhibitors
Hypercholesterolemia
L-arginin
Nitric oxide metabolites
Simvastatin
Thiols
Abstract in English
The aim of this study was to evaluate the effect of sinvastatin, isolated and associated to α-tocopherol and to L-arginine, on the endogenous inhibitors of nitric oxide synthase, on nitric oxide metabolytes and thiols, in hypercholesterolemic patients. A group of 16 hypercholesterolemic patients were analysed, acconting to the protocol: a washout period (without medication) of 1 month, sinvastatin (20 mg/day) for 2 months; sinvastatin (20 mg/day) + α-tocopherol (400U/day) for 2 months; sinvastatin (20 mg/day) for 1 months (washout period), sinvastatin (20 mg/day) + L-arginine (7g/day) for 2 months. Sinvastatin significantly reduced the concentrations of total cholesterol and LDL-cholesterol, as well as the LDL-cholesterol/HDLcholesterol ratio. The treatment with sinvastatina, alone and associate to α-tocoferol, resulted in a reduction of RSNO concentration. The L-arginine associated with sinvastatin, increase the level of total cholesterol as compared with simvastatin alone. The plasma concentrations of a-tocopherol and Larginine did not increase following supplementation due to the large dispersion of the data obtained, even though the median plasma concentrations of L-arginine and a-tocopherol were elevated after supplementation. Treatment with simvastatin, alone or associated to L-arginine and a-tocopherol did not alter the concentrations of the endogenous inhibitors of nitric oxide synthase (ADMA and SDMA), or that of nitric oxide metabolytes, total nitrotyrosine or the thiols analysed.
 
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Publishing Date
2010-05-04
 
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