Tesis Doctoral
DOI
https://doi.org/10.11606/T.9.2009.tde-25032010-162949
Documento
Autor
Nombre completo
Camila Figueiredo Borgognoni
Dirección Electrónica
Área de Conocimiento
Fecha de Defensa
Publicación
São Paulo, 2009
Director
Tribunal
Pitombo, Ronaldo Nogueira de Moraes (Presidente)
Ayrosa, Ana Maria Irene Bartolomeu
Maizato, Marina Junko Shiotsu
Polakiewicz, Bronislaw
Tattini Junior, Virgilio
Título en portugués
Otimização da liofilização do pericárdio bovino com o auxílio de ferramentas matemáticas
Palabras clave en portugués
Bioengenharia
Biotecnologia
Liofilização
Modelagem matemática
Pericárdio animal
Pericárdio bovino
Resumen en portugués
Título en inglés
Freeze-drying optimization of bovine pericardium by mathematical modeling
Palabras clave en inglés
Animal pericardium
Bioengineering
Biotechnology
Bovine pericardium
Freeze-drying
Mathematical modeling
Resumen en inglés
Freeze-drying is a method of preservation that provides high-quality dehydrated products. It is a process that requires time and energy and it may take days to finish. Freeze-drying optimization is used to minimize the process time keeping the high quality of the product. Mathematical models that predict the behavior of products during freeze-drying can drastically reduce the number of experiments and determine variables in a study that could not be experimentally measured. Biological tissues are sensitive to heat and might be irreversibly modified. The study of bovine pericardium freeze-drying improves its handling and storage. The purpose of this project was to determine key parameters which served to guide the development of a mathematical model able to describe the bovine pericardium freeze-drying process and achieve its validation. The study of the freezing step in the bovine pericardium freeze-drying was done by analyzing the time of the process and the residual moisture content of the dried product. Mathematical modeling of the process was shown from the determination of sublimation rates by freeze-drying microscopy under different chamber pressures and heating rates. The freeze-dried products were evaluated for the maintenance of their physical properties. The results revealed that slow freezing with thermal treatment had short process time and low residual moisture of the final product. The mathematical model demonstrated the bovine pericardium freeze-drying and the product indicated no change in their physical properties after the process. Thus, the freeze-drying microscopy analysis was validated in determining the sublimation rate during the bovine pericardium freeze-drying and the process was endorsed through mathematical modeling.

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Fecha de Publicación
2010-05-04