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Master's Dissertation
DOI
https://doi.org/10.11606/D.85.2022.tde-10032023-121043
Document
Author
Full name
Orion Giovane Tasso
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2022
Supervisor
Committee
Zamboni, Cibele Bugno (President)
Silva, Dalton Giovanni Nogueira da
Simons, Simone Michaela
Title in Portuguese
Comparação de desempenho do espectrômetro portátil de fluorescência de raios-X utilizando alvos de Au e Ag para análise de amostras na área da saúde
Keywords in Portuguese
dosagem de íons
FRX
soro
teste clínico
urina
Abstract in Portuguese
Este trabalho teve por objetivo avaliar o desempenho do espectrômetro portátil e compacto de Fluorescência de Raios X (pFRX), para análise de elementos químicos em amostras biológicas de interesse na área da saúde humana (prioritariamente fluidos corpóreos como soro e urina) bem como para medicina veterinária, utilizando alvos de prata (Ag) e ouro (Au). O foco das comparações foi direcionado às análises quantitativas de elementos de relevância clínica e nutricional (prioritariamente a dosagem de Ca, Cl, Fe, K, P e S). Para este estudo foram avaliados, para cada alvo, os parâmetros: linearidade, reprodutibilidade, acurácia, sensibilidade e limite de detecção. Essas investigações permitiram a realização de um estudo comparativo entre os alvos com a finalidade de fornecer subsídios que permitem a escolha adequada do alvo (Ag e/ou Au), agilizando as medidas além de fornecer resultados mais precisos.
Title in English
Performance comparison of portable X ray fluorescence spectrometer using Au and Ag targets for sample analysis in healthcare
Keywords in English
clinical test
ion dosage
serum
urine
XRF
Abstract in English
This study aimed to evaluate the performance of the portable and compact X-ray Fluorescence spectrometer (pXRF) for the analysis of chemical elements in biological samples of interest in the health area (primarily body fluids, such as, serum and urine) as well as for veterinary medicine using targets of the Silver (Ag) and Gold (Au). The focus of the comparisons was directed to the quantitative analysis of elements of clinical and nutritional relevance (mainly the dosage of Ca, Cl, Fe, K, P, S, Br and Zn). For this study, the following parameters were evaluated (for each target): linearity, reproducibility, accuracy, sensitivity and detection limit. These investigations made it possible to carry out a comparative study between the targets in order to provide subsidies that allow the appropriate choice of the target (Ag and/or Au), speeding up measurements in addition to providing more accurate results.
 
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Publishing Date
2023-03-16
 
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