• JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
 
  Bookmark and Share
 
 
Master's Dissertation
DOI
https://doi.org/10.11606/D.74.2022.tde-09022023-153112
Document
Author
Full name
Wellington Henrique Bessi
Institute/School/College
Knowledge Area
Date of Defense
Published
Pirassununga, 2022
Supervisor
Committee
Freitas, Silvio Henrique de (President)
Minto, Bruno Watanabe
Rigo, Eliana Cristina da Silva
Title in Portuguese
Análise das interfaces entre compósitos constituídos de matrizes ósseas mineralizadas heterólogas trabeculares canina (MOMHTc) e de bovina (MOMHTb) associadas à quitosana e as falhas ósseas de tíbias de coelhos
Keywords in Portuguese
Biomateriais
Falha óssea
Osseointegração
Substituto ósseo
Abstract in Portuguese
Na medicina veterinária e humana são frequentes afecções ortopédicas que necessitam de intervenção cirúrgica a fim de repor tecido ósseo, seja através de enxerto ósseo, implante natural e/ou sintético. Como método associativo entre os materiais pré-existentes, objetivou-se analisar as interfaces entre os compósitos de MOMHTc e MOMHTb associados à quitosana utilizando-se 12 coelhos adultos da raça Nova Zelândia, que foram submetidos a falhas ósseas tibiais. Os resultados revelaram que os compósitos apresentaram potencial citotóxico. Nas avaliações radiográficas digitais (projeção médio-lateral) todos os compósitos implantados encontravam-se acomodados em seus leitos receptores e com gradativa mudança de densidade em suas interfaces pelo período observado. Macroscopicamente, os compósitos constituídos de MOMHTc/b e quitosana permaneceram em seus leitos receptores, com excessão a um compósito constituído de MOMHTc e quitosana. Análises por meio da MEV/EDS demonstraram que dos 24 compósitos constituídos de MOMHT(c/b) e quitosana implantados nas tíbias de coelhos, 23 foram incorporados em seus respectivos leitos receptores e apenas oito foram osseointegrados, sendo cinco de origem bovina e três de canina. Dos compósitos implantados e analisados, os constituídos de MOMHTb associados a quitosana apresentaram melhor performance, sendo esse biomaterial o mais recomendado como substituto para preencher e reparar falhas ósseas não críticas.
Title in English
Analysis of the interfaces between composites constituted of mineralized heterologous canine trabecular bone (MOMHTc) and bovine (MOMHTb) matrices associated with chitosan and as bone defects of rabbit tibiae
Keywords in English
Biomaterials
Bone failure
Bone substitute
Osseointegration
Abstract in English
In veterinary and human medicine, orthopedic disorders that require surgical intervention are common in order to replace bone tissue, either through bone graft, natural and/or synthetic implants. As an associative method between pre-existing materials, the objective was to analyze the interfaces between the composites of MOMHTc and MOMHTb associated with chitosan using 12 adult New Zealand rabbits, which were submitted to tibial bone defects. The results revealed that the composites showed cytotoxic potential. In the digital radiographic evaluations (mediolateral projection) all implanted composites were accommodated in their receiving beds and with a gradual change in density at their interfaces for the observed period. Macroscopically, the composites consisting of MOMHTc/b and chitosan remained in their receptor beds, with the exception of a composite consisting of MOMHTc and chitosan. Analysis through SEM/EDS showed that of the 24 composites made up of MOMHT(c/b) and chitosan implanted in the tibiae of rabbits, 23 were incorporated into their respective receptor beds and only eight were osseointegrated, five of bovine origin and three of canine. Of the composites implanted and analyzed, those made of MOMHTb associated with chitosan showed the best performance, and this biomaterial is the most recommended as a substitute for filling and repairing non-critical bone defects.
 
WARNING - Viewing this document is conditioned on your acceptance of the following terms of use:
This document is only for private use for research and teaching activities. Reproduction for commercial use is forbidden. This rights cover the whole data about this document as well as its contents. Any uses or copies of this document in whole or in part must include the author's name.
ME10973572COR.pdf (3.65 Mbytes)
Publishing Date
2023-02-10
 
WARNING: Learn what derived works are clicking here.
All rights of the thesis/dissertation are from the authors
CeTI-SC/STI
Digital Library of Theses and Dissertations of USP. Copyright © 2001-2024. All rights reserved.