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Master's Dissertation
DOI
10.11606/D.7.2010.tde-18012011-163141
Document
Author
Full name
Wanessa Teixeira Silva
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2010
Supervisor
Committee
Vattimo, Maria de Fatima Fernandes (President)
Magro, Marcia Cristina da Silva
Neiva, Luciana Barros de Moura
Title in Portuguese
Efeito protetor de fitomedicamento Vitis Vinifera L na lesão renal aguda induzida pelo Tacrolimus
Keywords in Portuguese
lesão renal aguda. Nefrotoxicidade. Antioxidantes. Tacrolimus. Vitis vinifera L
Abstract in Portuguese
As lesões renais agudas (LRAs) nefrotóxicas correspondem a 30% dos casos de LRA. A nefrotoxicidade é efeito indesejável de diversos fármacos de uso rotineiro na clínica, entre eles as drogas imunossupressoras. A nefrotoxicidade do Tracolimus (Fk 506) é uma das causas de LRA após o transplante renal. Com a ampla utilização do Fk 506 nas terapias imunossupressoras e devido ao seu potencial nefrotóxico que pode levar à perda do enxerto, o objetivo desse estudo foi avaliar o efeito renoprotetor do extrato de Vitis vinifera L, um fitomedicamento com efeito antiinflamatório e antioxidante, na nefrotoxicidade induzida pelo Tacrolimus em ratos. Foram utilizados ratos Wistar, machos, adultos, pesando entre 250 - 300g, todos tratados 1x/dia por 5 dias, conforme os seguintes grupos: Salina (grupo controle) (NaCl 0,9%, 0,1ml por gavagem); Vitis (Vitis vinifera L 3mg/kg por gavagem), Fk (Tacrolimus 0,5mg/kg por gavagem) e Fk+Vitis (Tacrolimus 0,5mg/kg + 3mg/kg por gavagem). Foram avaliados a função renal (FR) (clearance de creatinina, método Jaffé); os peróxidos urinários (PU) (FOX-2), o malondealdeído (MDA-TBARS) e a histologia renal. Os dados desse estudo confirmaram a lesão nefrotóxica de caráter oxidativo induzida pelo Tacrolimus. A Vitis vinifera L demonstrou efeito renoprotetor significativo, com melhora na FR, redução dos níveis de peroxidação lipídica e proteção histológica. Esse estudo confirmou a renoproteção da Vitis vinifera L na LRA induzida pelo Tacrolimus.
Title in English
Protective effect of the phytomedicine Vitis Vinifera L in acute kidney injury by Tacrolimus
Keywords in English
acute kidney injury. Nephrotoxicity. Antioxidants. Tacrolimus. Vitis vinifera L
Abstract in English
The nephrotoxic injury corresponds to 30% of the acute kidney injury (AKI) cases. Nephrotoxicity is an undesirable effect of several drugs used in the clinic, among them, the imunossupressoras drugs. The Tacrolimus (FK 506) nephrotoxicity is the main cause of AKI after kidney transplantation. Being Fk 506 widely used in the immunessupressive therapies and due to its nephrotoxic effect that can lead to the loss of graft, the aim of this study was evaluate the renoprotective action of Vitis Vinifera L extract , a phitomedicine with antioxidant and antinflammatory effects in the nephrotoxicity induced by FK 506 in rats. Wistar rats, male, adults, weight ranging from 250-300g were used, all treated once/day for 5 days, as the following groups: Saline (control group) (NaCl 0.9%, 0,1ml per gavage), Vitis (Vitis vinifera L, 3mg/Kg per gavage), FK (Tacrolimus 0.5mg/Kg per gavage) and FK+Vitis (Tacrolimus 0.5mg/Kg per gavage + Vitis vinifera L, 3mg/Kg per gavage). Renal Function (RF) (creatinine clearance, Jaffé method), urinary peroxides (FOX-2), malondialdehyde (MDA-TBARS) and the kidney histological were evaluated. The data of this study confirmed the oxidative kidney injury by Tacrolimus. The Vitis vinifera L showed significant renoprotective effect, with improvement in the RF, a reductin in lipid peroxidation and histological protection. This study confirmed the renoprotective effect of Vitis Vinifera in the AKI by Tacrolimus.
 
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Publishing Date
2011-02-22
 
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