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Doctoral Thesis
DOI
10.11606/T.6.2016.tde-03082016-173959
Document
Author
Full name
Pedro Manuel Leal Germano
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 1981
Supervisor
Committee
Paim, Gil Vianna (President)
Candeias, José Alberto Neves
Ishizuka, Masaio Mizuno
Qualifik, Paul
Souza, Jose Maria Pacheco de
Title in Portuguese
Estudo comparativo entre as provas de soroneutralização e imunofluorescência indireta para a avaliação de anticorpos anti-rábicos em soros de cães, e avaliação do comportamento da vacina anti-rábica preparada em cérebros de camundongos lactentes, aplicada em cães primo vacinados, em condições naturais
Keywords in Portuguese
Imunologia Rábica
Raiva Canina
Saúde Pública
Vacina Antirrábica
Veterinária
Abstract in Portuguese
Procedeu-se ao estudo comparativo entre as provas de soroneutralização (SN) e imunofluorescência indireta (IFI) para a avaliação de anticorpos anti-rábicos em soros de cães. A prova de IFI apresentou associação significante de alta ntensidade e elevada concordância com a prova de SN, não se verificando, porém, correlação significante entre os resultados obtidos por ambas as provas. A avaliação do comportamento da vacina anti-rábica, preparada em cérebros de camundongos lactentes e aplicada em cães nunca antes vacinados, revelou pela prova de SN uma ascensão lenta e de pequena magnitude e um declínio rápido, da curva das medianas dos títulos de anticorpos anti-rábicos, já aos 45 dias da vacinação. Relativamente à prova de IFI, a resposta imunitária revelou-se mais intensa, e o declínio da curva das medianas dos títulos de anticorpos ocorreu aos 60 dias da vacinação.
Title in English
Comparative study of the evidence of neutralization and indirect immunofluorescence for the evaluation of anti-rabies antibodies in sera from dogs, and performance evaluation of rabies vaccine prepared in the brains of newborn mice, applied in vaccinated dogs cousin in natural conditions
Keywords in English
Canine Rabies
Rabies Immunology
Rabies Vaccine
Veterinary Public Health
Abstract in English
A comparative study was made between the serum-neutralization (SN) and indirect immunofluorescence CIIF) techniques for the evaluation of rabies antibodies in sera from dogs. The IIF technic showed significant association of high intensity and concordance with the SN technic. No significant correlation, however, was observed between the results obtained from both techniques. The evaluation of the suckling-mouse-brain rabies vaccine, applied in dogs never vaccinated before, showed by the SN technic a slow rise of small magnitude and a fast decline of the curve of the median rabies antibodies titers, as early as 4S days after vaccination. With regard to the IIF technic, the immunitary reaction showed itself more sensitive, and the decline of the curve of the median antibodies titers occurred 60 days after vaccination.
 
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Publishing Date
2016-08-03
 
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