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Doctoral Thesis
DOI
https://doi.org/10.11606/T.6.2005.tde-19042021-100304
Document
Author
Full name
Fernanda Alves Cangerana Pereira
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2005
Supervisor
Committee
Cardoso, Maria Regina Alves
Assunção, João Vicente de
Dolhnikoff, Marisa
Mauad, Thais
Ribeiro, Helena
Title in Portuguese
Efeito da poluição do ar na carcinogênese de camundongos
Keywords in Portuguese
Câncer
Carcinogênese Ambiental
Poluição do Ar
Uretana
Abstract in Portuguese
Este estudo buscou avaliar o potencial da poluição na promoção de neoplasias utilizando camundongos como modelo experimental. Os camundongos foram colocados em câmaras de topo aberto, nas seguintes condições de exposição: Ar Limpo, com filtro para partículas e gases; Intermediário, com filtro para gases e Ar Sujo, sem filtragem. Em cada câmara os camundongos foram divididos em dois grupos, um recebeu n-nitroso-metil-uretana (2g por quilo de peso) e o outro serviu de controle recebendo solução salina . Os camundongos foram acompanhados por 2 meses. Os pulmões foram pesados e instilados com formol tamponado, foram observados macroscopicamente quanto à presença de tumores. A contagem macroscópica de nódulos demonstrou que existem diferenças entre os grupos. Os animais que receberam solução salina não apresentaram nódulos não importando as condições de exposição, o grupo que ficou exposto na câmara limpa apresentou uma média de 2,2 nódulos, o grupo da câmara intermediária teve como média o valor de 3,3 nódulos e o grupo da câmara suja 4,6 nódulos. A análise estatística demonstrou haver diferenças entre a câmara limpa uretana e a câmara suja uretana. Este estudo demonstrou que os poluentes do ar podem promover neoplasias pulmonares.
Title in English
Effect of air pollution on mouse carcinogenesis
Keywords in English
Air Pollution
Cancer
Environmental Carcinogenesis
Urethane
Abstract in English
This study aims to evaluate the potential of air pollution on neoplasms promotion using mouse as a experimental model. Mice were placed in open top chamber, on the following conditions: Clean air, with filtration of gases and particles; Intermediary, with filtration of gases only and Dirty air, without filter. In each chamber mouse were divided in two groups, one of then received urethane (2g/k of weigh) and the other was control group receiving salina solution. Mice were maintained in the chambers for two months. After this period animals were death and lungs were weigh and instilled with formol, nodules were counted. Nodules count showed differences between the groups. Control animals did not present any nodule no matter the chamber they were placed. In the urethane group, the animals placed in the clean chamber presented an average of 2,2 nodules per animal, in the intermediary chamber the average was 3,3 per animal and in the dirty chamber the average was 4,6 nodules. Statistic showed that dirty chamber urethane group was different from clean chamber urethane group. This study showed that air pollutant can promote lung neoplasms.
 
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Publishing Date
2021-04-19
 
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