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Doctoral Thesis
Full name
Maria Lucia de Moura Silva Soboll
Knowledge Area
Date of Defense
São Paulo, 1985
Souza, Jose Maria Pacheco de (President)
Gotlieb, Sabina Lea Davidson
Mirra, Antonio Pedro
Qualifik, Paul
Wilson, Donald
Title in Portuguese
Câncer de reto: estudo caso-controle no município de São Paulo
Keywords in Portuguese
Câncer de Reto
Consumo de Alimentos
Abstract in Portuguese
Trata-se de um estudo caso-controle de câncer de reto como parte do "Estudo Epidemiológico de Câncer de Esôfago e de Reto no Município de são Paulo". O estudo compreendeu 92 casos de cancer de reto e 200 controles categorizados em 3 sub-conjuntos (amostra pareada, global e estratificada). Foram objeto de análise as variáveis: local de nascimento do indivíduo e de seus pais, zona de nascimento (rural/urbana) consumo de alimentos (carnes, ovos, verduras, temperos) características do hábito intestinal, tabagismo e consumo de bebidas (cerveja, vinho e pinga). As estimativas dos Riscos Relativos (RR) por ponto e respectivos testes de significância foram calculados para cada tipo de amostra. Utilizou-se análise multivariada, através do procedimento de máxima verossimilhança condicional para a amostra estratificada e os procedimentos clássicos para as amostras pareada e global. A análise estatística dos resultados evidenciou associação positiva apenas entre o consumo de queijo e câncer de reto (RR = 1,41 I--------I 4,30). Não está afastada a possibilidade de que a significância encontrada seja devido a um artefato estatístico, dada a multiplicidade de testes efetuados. A possível associação entre o consumo queijo e câncer de reto, portanto, deve ser interpretada com reserva.
Title in English
Rectal cancer: case-control study in São Paulo
Keywords in English
Food Consumption
Rectal Cancer
Abstract in English
This is a case-control study of rectal cancer and is part of "The Epidemiological Study of Esophagus and Rectal Cancers in the City of são Paulo, Brazil". The study included 92 cases of rectal cancer and 200 controls (classified in three types: matched, global and stratified samples). The analised variables were: state of birth classified in great regions of Brazil, place of birth (rural/urban) ,food consumption (meats, eggs, fruits, vegetables, cereals, beans, seasonings, dairy products) caracteristics of the bowel movements, smoking habits and alcohol consumption (beer, wine and hard liquor-"pinga"). The point estimates of the Relative Risks and their significance tests were calculated for each type of sample. Multivariate analysis was done, for the stratified sample the conditional maximum likelihood procedure was used and classical procedures (Me Nemar and Cross Ratio estimate) for the other samples. The statistical analysis indicated a positive/association only between cheese consumption and cancer of the rectum (RR = 1,41 I------I 4,30). There is the possibility that the observed statistical significance is a statistical artefact due to the multiplicity of tests that have been perfomed. Because of this, the possible association between cheese consumption and cancer of the rectum must be viewed with caution.
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