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Master's Dissertation
DOI
10.11606/D.5.2016.tde-19122016-141644
Document
Author
Full name
Walmyr Ribeiro de Mello
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2016
Supervisor
Committee
Bydlowski, Sergio Paulo (President)
Coracin, Fábio Luiz
Souza, Heraldo Possolo de
Title in Portuguese
Análise dos fatores que influenciam o desenvolvimento da mucosite oral em transplante de células-tronco hematopoiéticas autólogo
Keywords in Portuguese
Células-tronco hematopoéticas
Estomatite
Mucosite
Quimioterapia
Transplante autólogo
Transplante de células-tronco
Abstract in Portuguese
A mucosite é um efeito grave e dose-limitante do tratamento antineoplásico, cujas lesões ulceradas apresentam grande impacto na morbidade e mortalidade dos pacientes, por apresentar dor, restrição alimentar e servindo como porta de entrada para infecções originadas da mucosa bucal, com incidência variável de acordo com a doença de base, idade, condição de saúde bucal, dose e frequência da quimioterapia. A ocorrência de mucosite oral é frequente nos pacientes que receberam altas doses de quimioterapia seguidas de transplante autólogo de células tronco hematopoiéticas. O objetivo deste estudo foi analisar os fatores que influenciam o desenvolvimento da mucosite oral. Foi realizada uma análise retrospectiva em 413 prontuários de pacientes consecutivos submetidos ao transplante autólogo de células tronco hematopoiéticas e os dados coletados incluíram dados demográficos (sexo, idade, doença de base), dados do TCTH (tipo de transplante, regime de condicionamento) e incidência de mucosite oral. Os resultados deste estudo mostraram que a incidência de mucosite foi maior em pacientes do sexo masculino e nos pacientes do sexo feminino com idade média de 29 anos, nos pacientes submetidos ao regime de condicionamento BU/MEL e naqueles pacientes portadores de LMA. Os resultados deste estudo permitiram concluir que a incidência de mucosite oral na casuística analisada foi maior nos pacientes do sexo masculino; nas mulheres jovens quando analisados sexo e idade separadamente, nos pacientes portadores de LMA e naqueles submetidos ao regime de condicionamento BU/MEL
Title in English
Analysis of factors that influence the oral mucositis development in autologous stem cell transplantation
Keywords in English
Drug therapy
Hematopoietic stem cells
Mucositis
Stem cell transplantation
Stomatitis
Transplantation autologous
Abstract in English
Oral mucositis remains as a serious and dose-limiting side-effect of antineoplastic treatment and ulcerated lesions lead to a great impact on morbidity and mortality of patients due to pain, food restriction and serving as a gateway to originate infections of the oral mucosa patients. The incidence of oral mucositis remains uncertain and it is variable according to the underlying disease, age, oral health condition, dose and frequency of chemotherapy. The incidence of oral mucositis is high in patients receiving high-dose chemotherapy followed by autologous transplantation of hematopoietic stem cells. The aim of this study was to analyze the factors that influence the development of oral mucositis. a retrospective analysis of 413 medical records of consecutive patients undergoing autologous hematopoietic stem cell transplantation. Data collected included demographic data was performed (sex, age, underlying disease), HSCT data (type of transplant conditioning regimen) and incidence oral mucositis. The results of this study showed that the incidence of mucositis was higher in male patients and female patients with a mean age of 29 years, in patients undergoing conditioning regimen comprises BU / MEL and in those patients with AML. The results of this study showed that the incidence of oral mucositis in the analyzed sample was higher in males; in young women when analyzed separately sex and age, in patients with AML and those submitted to the BU / MEL conditioning regimen
 
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Publishing Date
2016-12-19
 
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