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Doctoral Thesis
DOI
10.11606/T.5.2005.tde-05092005-120436
Document
Author
Full name
Hermes Vieira Barbeiro
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2005
Supervisor
Committee
Soriano, Francisco Garcia (President)
Cirino, Luis Marcelo Inaco
Cunha, Fernando de Queiroz
Curi, Rui
Krieger, Marta Helena
Title in Portuguese
"Avaliação temporal da regulação do tônus vascular e da produção de superóxido induzido por purinas em aorta isolada de ratos Wistar endotoxêmicos"
Keywords in Portuguese
AORTA
ENDOTÉLIO VASCULAR
ENDOTOXEMIA
ESTRESSE OXIDATIVO
NUCLEOTÍDEOS DE PURINA/farmacologia
ÓXIDO NÍTRICO
RATOS WISTAR
Abstract in Portuguese
Pacientes sépticos podem evoluir para choque séptico, destes 40% sobrevivem. Caracterizamos o modelo experimental, avaliamos fatores envolvidos na inflamação e avaliamos a modulação causada por purinas (ATP/ADP) na quantificação de superóxido (O2-) e na reatividade vascular da aorta isolada. Os resultados sugerem que na aorta isolada de animais endotoxêmicos, ATP e ADP aumentam a síntese de óxido nítrico (NO), porém somente o ATP reduz a biodisponibilidade de O2-, provavelmente pelo reacoplamento da NO sintase endotelial
Title in English
Time course evaluation of vascular tonus and superoxide production from isolated purines in aorta of endotoxemics Wistar rats
Keywords in English
AORTA
ENDOTHELIUM VASCULAR
ENDOTOXEMIA
NITRIC OXIDE
OXIDATIVE STRESS
PURINE NUCLEOTIDES/pharmacology
RATS WISTAR
Abstract in English
Septic patients can evolve for septic shock and 40% of these survive. We characterize the experimental model we evaluate involved factors in the inflammation and evaluate the modulation caused by purines (ATP/ADP) in the superoxide quantification (O2-) and in the vascular reactivity of isolated aorta. The results suggest that in isolated aorta of endotoxemics rats, ATP and ADP increase the endothelial nitric oxide synthase (NOS) however just ATP reduces the bio availability of O2-, probably for the re-couples of the endothelial NOS synthase
 
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Publishing Date
2005-10-07
 
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