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Doctoral Thesis
DOI
10.11606/T.5.2004.tde-09082005-111153
Document
Author
Full name
Rosangela Monteiro
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2004
Supervisor
Committee
Jatene, Fabio Biscegli (President)
Prado, Isaura Maria Mesquita
Salerno, Pedro Rafael
Stolf, Noedir Antonio Groppo
Stopiglia, Angelo João
Title in Portuguese
"Avaliação das alterações anatômicas cardíacas secundárias ao enfisema pulmonar: estudo experimental em ratos"
Keywords in Portuguese
ENFISEMA PULMONAR/fisiopatologia
ENFISEMA PULMONAR/induzido quimicamente
MODELOS ANIMAIS DE DOENÇAS
PAPAÍNA/farmacologia
RATOS WISTAR
VENTRÍCULO CARDÍACO/anatomia & histologia
Abstract in Portuguese
Analisamos as alterações cardíacas pós-indução de enfisema por instilação de papaína. Foram avaliados 75 ratos (grupos papaína e controle), sacrificados 30, 60, 90, 120 ou 180 dias pós-instilação. Foram realizados: gasometria do sangue arterial, avaliação morfométrica cardíaca e pulmonar. A papaína produziu destruição alveolar compatível com enfisema, sem repercussão nas trocas gasosas. Ventrículo direito e septo interventricular não apresentaram alterações significativas. Houve redução da área do ventrículo esquerdo, 90 dias pós-indução, e discreto espessamento de sua parede.
Title in English
Evaluation of the cardiac anatomical alterations secondary to the pulmonary emphysema : experimental study in rats
Keywords in English
ANIMAL DISEASE MODELS
HEART VENTRICLES/anatomy & histology
PAPAIN/pharmacology
PULMONARY EMPHYSEMA/chemically induced
PULMONARY EMPHYSEMA/physiopathology
RATS WISTAR
Abstract in English
Cardiac alterations post-induction emphysema by instillation of papain were analyzed. Seventy-five rats (groups papain and control), sacrificed 30, 60, 90, 120 or 180 days post-instillation were evaluated. Arterial blood gases, cardiac and pulmonary morphometrical analysis were performed. Papain administration produced alveolar destruction compatible with emphysema, without arterial blood gases changes. Right ventricle and interventricular septum didn't show alterations. There were left ventricular area decrease (90 days post-induction) and light thickness increase of its wall.
 
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tesedomingonoite.pdf (526.10 Kbytes)
Publishing Date
2005-08-09
 
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