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Doctoral Thesis
DOI
10.11606/T.5.2005.tde-15102014-094132
Document
Author
Full name
Rosimeire Aparecida Roela
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2005
Supervisor
Committee
Brentani, Maria Mitzi (President)
Dias Neto, Emmanuel
Onuchic, Luiz Fernando
Kitten, Gregory Thomas
Metze, Irene Gyongyver Heidemarie Lorand
Title in Portuguese
Caracterização molecular do estroma conjuntivo de medula óssea de pacientes com síndrome mielodisplásica na infância
Keywords in Portuguese
Biologia molecular
Crianças
Medula óssea/anormalidades
Abstract in Portuguese
Analisamos por cDNA microarray o perfil gênico de células estromais da medula óssea de crianças com síndromes mielodisplásica (SMD), leucemia mielóide aguda associada à SMD (SMD/LMA) em comparação a crianças saudáveis. Os genes diferencialmente expressos durante a transformação e evolução da SMD codificam GTPases, proteínas relacionadas a microtúbulos, matriz extracelular, tráfico de membrana, via do fas e ponto de checagem mitótico. Estes genes estão envolvidos com processos celulares tais como apoptose e proliferação, os quais podem contribuir para a patologia da SMD
Title in English
-
Keywords in English
Bone marrow/abnormalities
Child
Molecular biology
Abstract in English
We have compared the gene expression profile by cDNA microarray analysis of bone marrow stromal cells from childhood myelodysplasic syndromes (MDS), MDS-associated acute myeloid leukemia (MDS/AML) as compared with healthy children. The genes differentially expressed during the SMD transformation and evolution were associated with GTPases, microtubule formation, matrix extracellular components, membrane trafficking, fas pathway and mitotic checkpoints. These genes were involved with cellular processes, such as apoptosis and proliferation which might contribute to MDS pathology
 
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Publishing Date
2014-10-15
 
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