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Doctoral Thesis
DOI
10.11606/T.5.2006.tde-06022007-110719
Document
Author
Full name
Léa Beltrão de Medeiros Speranzini
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2006
Supervisor
Committee
Laudanna, Antonio Atilio (President)
Campos, Fábio Guilherme Caserta Maryssael de
Damião, Aderson Omar Mourão Cintra
Fonseca, Angela Maggio da
Kiss, Desiderio Roberto
Title in Portuguese
A atividade mioelétrica colônica em ratas sob diferentes estados hormonais: influência de altos níveis de estrógeno, progesterona e da prenhez: estudo experimental in vivo
Keywords in Portuguese
Cólon
Eletrodos
Estrogênios
Progesterona Prenhez
Ratos Wistar
Abstract in Portuguese
Sendo a constipação intestinal queixa freqüente em gestantes, procuramos verificar se o complexo hormonal da gestação, e em especial a progesterona, diminui a atividade muscular colônica. Para tanto, estudamos in vivo o registro do sinal mioelétrico, sob diferentes estados hormonais, em quatro pontos do cólon de ratas: ascendente proximal, ascendente distal, médio e cólon descendente por meio de implante de eletrodos na camada sero-muscular colônica. As ratas foram divididas em 5 grupos: controle, ooforectomizadas, ooforectomizadas tratadas com estrógeno, ooforectomizadas tratadas com progesterona e ratas prenhes. Os resultados mostraram uma maior atividade elétrica no cólon proximal em ratas prenhes e nas pré-tratadas com progesterona. Nas ratas prenhes a duração da atividade elétrica máxima foi, de modo significante, maior em todas as distâncias quando comparada com ratas controle. Os resultados sugerem que in vivo a progesterona e o complexo hormonal da prenhez aumentam a atividade mioelétrica do cólon proximal e que a prenhez aumenta a duração da atividade elétrica máxima no cólon em cada distância estudada, levando à formação de fezes mais desidratadas. Progesterona e prenhez não devem ser responsabilizadas por hipomotilidade do cólon, uma das hipóteses que poderia explicar a constipação intestinal em gestantes
Title in English
Colon myoelectric activity in rats under different hormonal status. Influence of high levels of estrogen, progesterone and pregnancy. Experimental study in vivo
Keywords in English
Animal
Colon
Electrodes
Estrogens
Pregnancy
Progesterone
Rats Wistar
Abstract in English
The aim of this study was to find out if the hormonal complex of pregnancy, especially progesterone, could be responsible for decreasing colon myoelectric activity in female rats. We analyzed the records of colon myoelectric activity in vivo using the method of musculoserosal implantation of electrodes in four regions of the colon: proximal ascendent colon, distal ascendent colon, medial colon and descendent colon. The rats were divided in five groups: control, ovariectomized, ovariectomized and treated with estrogen, ovariectomized and treated with progesterone and pregnant rats. The results showed a greater electric activity in the proximal colon in pregnant and progesterone pretreated rats. In pregnant rats the duration of maximum electric activity was significantly greater in all distances studied. The results suggest that in vivo progesterone and the hormonal complex of pregnancy increase myoelectric activity of the proximal colon, and that pregnancy increases the duration of the maximum electric activity of the colon in every distance studied leading to more dehydrated fecal material. Progesterone and pregnancy should not be responsible for colon hypomotility, one of the hypothesis that could explain intestinal constipation in pregnant women
 
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Publishing Date
2007-02-06
 
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