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Doctoral Thesis
Full name
Ana Patricia do Nascimento
Knowledge Area
Date of Defense
São Paulo, 2007
Bonfa, Eloisa Silva Dutra de Oliveira (President)
Novaes, Gilberto Santos
Sato, Emilia Inoue
Schainberg, Claudia Goldenstein
Woronik, Viktoria
Title in Portuguese
Anticorpos anti-proteína p ribossômica: um potencial marcador sorológico para glomerulonefrite lúpica membranosa
Keywords in Portuguese
Glomerulonefrite membranosa
Lúpus eritematoso sistêmico
Marcadores biológicos
Nefrite lúpica
Abstract in Portuguese
O anticorpo anti-proteína P ribossomal é um marcador sorológico do lúpus eritematoso sistêmico. Nós avaliamos a relevância do mesmo em discriminar os padrões histopatológicos de nefrite lúpica. O anti-P foi detectado em 18/81(22%) dos pacientes com envolvimento renal confirmado por biópsia. Foi observada uma freqüência aumentada deste anticorpo em pacientes com classe V (72%) comparado com outras classes de nefrite (28%), p=0.005. Dentro do esperado, pacientes anti-P positivos tiveram um nível médio de proteinúria mais elevado que pacientes anti-P negativos (6,4 + 4,8 vs. 4,7 + 3,9 g/dl, p= 0,046). É ainda interessante que a maioria dos pacientes com anti-P isolado tinha classe V, e 71%apresentaram o padrão membranoso puro. O anti-P parece ser um novo marcador sorológico para a nefrite lúpica membranosa.
Title in English
Antibodies to ribosomal P proteins: a potential serological marker for lupus menbranous glomerulonphritis
Keywords in English
Biological markers
Glomerulonephritis membranous
Lupus erythematosus systemic
Lupus nephritis
Abstract in English
Anti-ribosomal P antibody is a serological marker for systemic lupus erythematosus. We have evaluated its relevance in discriminating histopathologic patterns of lupus nephritis. Anti-P was detected in 18/81 (22%) patients with biopsy proven renal involvement. A higher frequency of this antibody was observed in patients with class V (72%) compared to other classes of renal disease (28%), p=0.005. Accordingly, anti-P positive patients had higher mean proteinuria level than anti-P antibody negative patients (6.4 + 4.8 vs. 4.7 + 3.9 g/dl, p= 0.046). Interestingly, the majority of patients with isolated anti-P had class V, and 71% displayed a pure membranous pattern. Anti-P seems to be a novel serological marker for membranous lupus nephritis.
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