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Doctoral Thesis
DOI
10.11606/T.5.2005.tde-12042006-090739
Document
Author
Full name
Andrea Silveira de Souza
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2005
Supervisor
Committee
Bottino, Cassio Machado de Campos (President)
Louzã Neto, Mario Rodrigues
Nitrini, Ricardo
Okamoto, Ivan Hideyo
Schultz, Rodrigo Rizek
Title in Portuguese
"Espectroscopia de prótons na demência de Alzheimer e no comprometimento cognitivo"
Keywords in Portuguese
Análise espectral
Demência/diagnóstico
Doença de Alzheimer/diagnóstico
Doença de Alzheimer/fisiopatologia
Espectroscopia de ressonância magnética/métodos
Transtornos cognitivos/diagnóstico
Abstract in Portuguese
Estudamos os achados da espectroscopia de prótons no córtex parietal-cíngulo posterior e das escalas MEEM, BRDS e FAST em pacientes com doença de Alzheimer - DA, comprometimento cognitivo amnéstico - CCA e controles normais - CN. Apenas as razões NAA/Cr e MI/NAA diferenciaram (p < 0.002) os grupos DA e CN. Houve correlação significativa do NAA/Cr e do MI/NAA com o BRDS (pontuação total - PT; atividades cotidianas - AC) e FAST, e do MI/NAA com o MEEM. Houve acréscimo de 5% na especificidade (CN x DA; CN x CCA), e de 2.4% (CN x DA) e 3.4% (CN x CCA) na acurácia diagnóstica, ao adicionar as razões NAA/Cr e MI/NAA às escalas BRDS (PT e AC) e FAST, aumentando a detecção de indivíduos com CCA e DA
Title in English
Proton spectroscopy in Alzheimer's dementia and amnestic mild cognitive impairment
Keywords in English
Alzheimer disease/diagnosis
Alzheimer disease/physiopathology
Cognition disorders/diagnosis
Dementia/diagnosis
Magnetic resonance spectroscopy/methods
Spectrum analysis
Abstract in English
We studied the findings of proton spectroscopy of the posterior parietal-cingulate cortex, and of MMSE, BRDS and FAST scales in subjects with Alzheimer disease - AD, amnestic mild cognitive impairment - MCI-A and normal controls - NC. Only NAA/Cr and MI/NAA differentiated (p < 0.002) the AD and NC groups. Significant correlation was found between NAA/Cr and MI/NAA with BRDS (total score - TS; everyday activities - EA) and FAST scales, and between MI/NAA and MMSE. Specificity increased in 5% (NC x AD; NC x MCI-A) and diagnostic accuracy in 2.4% (NC x AD) and 3.4% (NC x MCI-A) when NAA/Cr and MI/NAA ratios were added up to BRDS (TS & EA) and FAST scales, increasing MCI-A and AD detectability
 
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Publishing Date
2006-04-12
 
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