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Doctoral Thesis
Full name
Marina Buarque de Almeida
Knowledge Area
Date of Defense
São Paulo, 2004
Silva Filho, Luiz Vicente Ribeiro Ferreira da (President)
Aquino, Maria Zilda de
Grisi, Sandra Josefina Ferraz Ellero
Ramos, Sonia Regina Testa da Silva
Torres, Lidia Alice Gomes Monteiro Marin
Title in Portuguese
Avaliação das infecções respiratórias virais em pacientes com fibrose cística
Keywords in Portuguese
Biologia molecular
Bocavirus humano
Fibrose cística
Infecções por paramyxoviridae
Vírus da influenza
Vírus sincicial respiratório
Abstract in Portuguese
O objetivo deste estudo foi avaliar o impacto clínico, funcional e bacteriológico das infecções respiratórias virais nos pacientes com fibrose cística durante um ano. A identificação viral foi feita por métodos de biologia molecular para os seguintes virus: Vírus sincicial respiratório, Influenza A e B, Parainfluenza 1, 2 e 3, Adenovírus, Rinovírus, Metapneumovírus humano, Coronavírus, Enterovírus e Bocavírus. Foram 408 amostras com identificação viral em 199 amostras (48,7%). O Rinovírus foi o mais prevalente sendo identificado em 140 amostras (34,31%), mas contrastando com outros estudos em fibrose cística e em outras doenças pulmonares crônicas, o Rinovírus não mostrou ter impacto clínico, funcional ou bacteriológico significativo nos pacientes com fibrose cística
Title in English
Respiratory viral infections evaluation in cystic fibrosis patients
Keywords in English
Cystic fibrosis
Human bocavirus
Influenza virus
Molecular Biology
Paramyxoviridae infections
Respiratory syncytial virus
Abstract in English
The objective of this study was to evaluate the clinical, functional and bacteriological impact of the viral respiratory tract infections in cystic fibrosis patients over one year. Viral identification was done through molecular biology methods for the following virus: Respiratory syncytial virus, Influenza A and B, Parainfluenza viruses type 1 to 3, Adenovirus, Rhinovirus, Human metapneumovirus, Coronavirus, Enterovirus and Human bocavirus. 199 (48,7%) samplings among 408 were positive for at least one virus. Rhinovirus was the virus with a higher prevalence, which was identified in 140 samplings (34,31%), but without clinical, functional or bacteriological impact contrasting with other studies in patients with cystic fibrosis and other chronic lung diseases
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