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Master's Dissertation
DOI
https://doi.org/10.11606/D.5.2022.tde-17012023-185933
Document
Author
Full name
Fernanda Marques de Deus
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2022
Supervisor
Committee
Krebs, Vera Lúcia Jornada (President)
Calil, Valdenise Martins Laurindo Tuma
Ferrer, Ana Paula Scoleze
Mataloun, Marta Maria Galli Bozzo
Title in Portuguese
Preditores de morbimortalidade em recém-nascidos prematuros de muito baixo peso
Keywords in Portuguese
CRIB II
Morbimortalidade neonatal
Mortalidade hospitalar
Pré-termo
SNAPPE-II
Troponina T
Abstract in Portuguese
Introdução: A prematuridade é um problema global. Os escores de risco servem como instrumento de comparação de mortalidade entre os serviços e de avaliação sobre o impacto das novas terapêuticas. Alguns estudos avaliam possíveis marcadores biológicos como preditores de morbimortalidade. Objetivos: Determinar e comparar as performances da dosagem de troponina T no sangue de cordão umbilical, Clinical Risk Index for Babies (CRIB-II), Score for Neonatal Acute Physiology, Perinatal extension - version II (SNAPPE-II), peso de nascimento, e idade gestacional como preditores de mortalidade e morbidade em recém-nascidos prematuros com peso de nascimento menor que 1500 gramas. Métodos: Estudo de coorte prospectivo numa Unidade de Tratamento Intensivo Neonatal de um Hospital Público Quaternário, entre 2015 e 2017. Critérios de inclusão: todos os nascidos vivos, com peso de nascimento (PN) entre 400 e 1499 gramas e idade gestacional (IG) entre 24 e 33 semanas e 6 dias. Recémnascidos que evoluíram para óbito em sala de parto, aqueles com malformações graves e/ou cromossomopatias e com hidropisia grave (nos quais a viabilidade foi considerada baixa) foram excluídos. Os desfechos primários avaliados foram: mortalidades neonatal e hospitalar. Os desfechos secundários foram: hemorragia peri-intraventricular (HPIV), displasia broncopulmonar (DBP) e retinopatia da prematuridade (ROP). A análise estatística foi realizada pela análise e comparação das curvas Receiver Operating Characteristic (ROC). Foram utilizados os teste de T-Student, Mann-Whitney e QuiQuadrado ou Teste Exato de Fisher, na comparação entre os grupos. Resultados: No período, nasceram 269 RN com os critérios de inclusão, destes foram excluídos 46 recém-nascidos. Houve uma perda de 74 pacientes, sendo estudados 149 RN. Não houve diferenças nos dados demográficos entre o grupo estudado e o grupo das perdas.. Na predição de óbito neonatal, as áreas sob a curva (Aroc) (intervalo de confiança) foram: PN de 0,813 (0,741-0,872), IG de 0,785 (0,710-0,848), CRIB-II de 0,785 (0,708-0,850), SNAPPE-II de 0,727 (0,648-0,797) e troponina T de 0,722 (0,643-0,792). Na predição de óbito hospitalar, as Aroc foram: PN de 0,809 (0,736-0,868), CRIB-II de 0,786 (0,709-0,851), IG de 0,769 (0,693-0834), troponina T de 0,743 (0,665-0,811) e SNAPPE-II de 0,729 (0,650-0,799). Com relação à ROP, as Aroc acima de 0,7 foram: SNAPPE-II de 0,776 (0,686-0,851) e PN de 0,735 (0,642-0,0,815). Na predição de DBP, as áreas acima de 0,7 foram: PN de 0,791 (0,704-0,862); SNAPPE-II de 0,751 (0,661-0,828); CRIB-II de 0,746 (0,650-0,826); IG de 0,742 (0,650-0,820). Para HPIV graves, as Aroc acima de 0,7 foram: SNAPPE-II de 0,718 (0,637-0,790) e IG de 0,712 (0,631-0,785). Conclusões: A troponina T teve performance satisfatória como variável independente na predição de mortalidade neonatal e hospitalar em recém-nascidos pré-termos de muito baixo peso, comparável aos escores mais utilizados nas unidades intensivas neonatais, no entanto, não obteve área abaixo da curva ROC acima de 0,7 na predição das morbidades estudadas
Title in English
Predictors of Morbidity and Mortality in Very Low Birthweight Preterm Infants
Keywords in English
CRIB-II
Indicators of morbidity and mortality
Preterm infant
SNAPPE-II
Troponin T
Very low birthweight
Abstract in English
Background: Prematurity is a global problem. Risk scores are instruments for comparing mortality between services and evaluating therapeutic advances. Some biological markers are studied as predictors of morbidity and mortality. Objectives: To determine and compare the performances of troponin T in umbilical cord blood, Clinical Risk Index for Babies (CRIB-II), Score for Neonatal Acute Physiology, Perinatal extension - version II (SNAPPE-II), birthweight, and gestational age as predictors of mortality and morbidities in preterm newborns with birthweight less than 1500 grams. Methods: Prospective cohort study was performed in a NICU of a Public Quartenary Hospital between 2015 and 2017. Inclusion: All live newborns with birthweight (BW) between 400 and 1499 grams and gestational age (GA) between 24 and 33 weeks and 6 days. Patients who died in the delivery room with severe malformations and/or chromosome diseases and severe hydrops (cases not considered viable) were excluded. Primary outcomes evaluated: neonatal and in-hospital mortality. Secondary outcomes: peri-intraventricular haemorrhage (PIVH), bronchopulmonary dysplasia (BPD), and retinopathy of prematurity (ROP). Statistical analysis: analysis and comparison of the Receiver Operating Characteristic (ROC) curves. Students t test, the MannWhitney test, and the chi-square test or Fisher's exact test was used to compare the groups. Results: A total of 269 patients were born. Among them, 46 were excluded. There was a loss of 74 patients, and 149 newborns were studied. There were no significant differences in demographic data between the studied group and loss group. For neonatal death prediction, the AUCs were: BW 0.813 (0.741,0.872), GA 0.785 (0.710,0.848), CRIB-II 0.785 (0.708,0.850), SNAPPE-II 0.727 (0.648,0.797,) and troponin T 0.722 (0.643,0.792). In-hospital death prediction: BW 0.809 (0.736,0.868), CRIB-II 0.786 (0.709,0.851), GA 0.769 (0.693,0.834), troponin T 0.743 (0.665,0.811), and SNAPPE-II 0.729 (0.650,0.799). Regarding ROP, the AUCs above 0.7 were 0.776 (0.686-0.851) for SNAPPE-II and 0.735 (0.642-0.0.815) for BW. In BPD prediction, the AUCs above 0.7 were: BW 0.791 (0.704-0.862), SNAPPE-II 0.751 (0.661-0.828), CRIBII 0.746 (0.650-0.826), and GA 0.742 (0.650-0.820). For severe HPIV, the areas above 0.7 were: SNAPPE-II 0.718 (0.637-0.790) and GA 0.712 (CI 0.631-0.785). Conclusions: Troponin-T performed satisfactorily as an independent variable in the prediction of neonatal and in-hospital mortality in very low birthweight preterm infants, however, it did not obtain area below the ROC curve above 0.7 in the prediction of the studied morbidities
 
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Publishing Date
2023-01-18
 
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