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Doctoral Thesis
DOI
10.11606/T.5.2005.tde-04012006-105538
Document
Author
Full name
Roberto Augusto Plaza Teixeira
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2005
Supervisor
Committee
Cristofani, Lilian Maria (President)
Camargo, Beatriz de
Maluf Junior, Paulo Taufi
Odone Filho, Vicente
Tone, Luiz Gonzaga
Title in Portuguese
"Fatores clínicos e biológicos para recidivas em tumores de Wilms localizados"
Keywords in Portuguese
GENES P53
GLICOPROTEÍNA P
NEFROBLASTOMA
PROGNÓSTICO
PROTEÍNA P53
RECIDIVA
Abstract in Portuguese
Apesar do excelente prognóstico dos tumores de Wilms (TW) localizados (estádios I e II) e de histologia favorável (HF), 10% deles recidivam. Em 122 pacientes com TW com essas características, diagnosticados de 1976 e 2001, analisamos alguns fatores clínicos, como a idade por ocasião do diagnóstico e peso do tumor, em todos os pacientes; fatores biológicos, como o TP53 e a glicoproteína-p, em 40 deles; e variáveis histológicas de microestadiamento (invasão de seio renal, cápsula tumoral, vasos intra-renais e pseudocápsula inflamatória) em 28 com TW em estádio I. Correlacionando todos esses fatores com a presença de recidiva, observamos que a chance maior de recidiva estatisticamente significativa somente foi verificada em pacientes com duas ou mais variáveis de microestadiamento e/ou peso tumoral maior que 550 g
Title in English
Clinical and biological factors for relapse in localized wilms' tumor
Keywords in English
GENES p53
NEPHROBLASTOMA
P-GLYCOPROTEIN
PROGNOSIS
PROTEIN p53
RECURRENCE
Abstract in English
In spite of the excellent prognosis of localized favorable histology (FH) of Wilms' tumor (WT), 10% of them will relapse. In 122 TW patients with these characteristics, diagnosed between 1976 and 2001, some clinical factors have been analyzed, such as age at diagnosis and tumor weight in all patients; biological factors, like TP53 and p-glycoprotein, in 40 of them; and microsubstaging histological variables (invasion of renal sinus, tumor capsule, intrarenal vessels, and inflammatory pseudocapsule). Correlating all of those factors with relapse, we have observed that only patients with the association of two or more microsubstaging variables and/or tumor weight over 550 g showed a statistically significant higher chance of relapse
 
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Publishing Date
2006-01-12
 
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