• JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
 
  Bookmark and Share
 
 
Master's Dissertation
DOI
https://doi.org/10.11606/D.5.2021.tde-10032022-111448
Document
Author
Full name
Aline Rocha Donato
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2021
Supervisor
Committee
Baracat, Edmund Chada (President)
Borges, João Bosco Ramos
Gonçalves, Rodrigo
Ruiz, Carlos Alberto
Title in Portuguese
Aspectos epidemiológicos, clinicopatológicos e terapêuticos de pacientes com tumor phyllodes borderline e maligno da mama
Keywords in Portuguese
Doença da mama fibrocística
Doenças da mama
Mama
Neoplasias da mama
Tumor filoide
Tumor filoide borderline
Tumor filoide maligno
Abstract in Portuguese
INTRODUÇÃO: Os tumores phyllodes borderline e maligno da mama apresentam tendência a rápido crescimento e possibilidade de evolução com metástases à distância. Exérese cirúrgica da lesão é o tratamento padrão-ouro, não havendo papel claro para as terapias adjuvantes na condução desses tumores. Foram avaliados dados epidemiológicos, clinicopatológicos e de tratamento, bem como os desfechos das pacientes com tumor phyllodes borderline e maligno acompanhadas em nossas instituições. MÉTODOS: Coorte retrospectiva com análise de dados coletados em prontuário com seguimento de janeiro de 2007 a dezembro de 2018, incluindo variáveis clínicas, patológicas e de seguimento, além de análise de fatores de risco e sobrevida. RESULTADOS: Foram incluídas no estudo 22 pacientes com tumor phyllodes borderline e 29 com tumor phyllodes maligno. Tumores malignos apresentaram maiores dimensões (p=0.013) e foram mais frequentemente tratados com mastectomia (p=0.007). Cirurgia conservadora (p=0.010), margens cirúrgicas comprometidas (p=0.020) e ausência de radioterapia adjuvante (p=0.002) foram associados com aumento de recidiva local. Na análise multivariada, pacientes que realizaram radioterapia apresentaram menor recidiva (aHR=0.06; IC95% 0.01-0.33). Pior sobrevida livre de doença foi observada nas pacientes com margens cirúrgicas comprometidas (p=0.034), pleomorfismo acentuado (p=0.045), necrose (p=0.048), e naquelas não submetidas à radioterapia (p=0.010). CONCLUSÃO: A realização de radioterapia adjuvante atuou como fator protetor, reduzindo o risco de recidiva local na coorte geral de tumores phyllodes e no subgrupo de tumores phyllodes malignosbreast disease; Breast diseases; Breast neoplasms.
Title in English
Epidemiological, clinicopathological and therapeutic aspects of patients with malignant and borderline phyllodes tumor of the breast
Keywords in English
Borderline phyllodes tumor
Breast
Breast diseases
Breast neoplasms
Fibrocystic breast disease
Malignant phyllodes tumor
Phyllodes tumor
Abstract in English
INTRODUCTION: Borderline and malignant phyllodes tumor of the breast tend to grow rapidly and may progress with distant metastases. Surgical excision of the lesion is the gold standard treatment, with no clear role for adjuvant therapies in the management of these tumors. Epidemiological, clinicopathological and treatment data were evaluated, as well as outcomes of patients diagnosed with borderline and malignant phyllodes tumor of the breast followed at our institutions. METHODS: Retrospective cohort with analysis of data collected from medical records, with follow-up from January 2007 to December 2018, including clinical, pathological and follow-up variables, in addition to the analysis of risk factors and survival. RESULTS: 22 patients with borderline phyllodes tumor and 29 with malignant phyllodes tumor were included in the study. Malignant tumors had larger dimensions (p=0.013) and were more frequently treated with mastectomy (p=0.007). Conservative surgery (p=0.010), positive surgical margins (p=0.020) and absence of adjuvante radiotherapy (p=0.002) were associated with increased local recurrence. In multivariate analysis, patients who underwent radiotherapy showed less recurrence (aHR=0.06; IC95% 0.01-0.33). Worse disease-free survival was observed in patients with positive surgical margins (p=0.034), marked pleomorphism (p=0.045), necrosis (p=0.048) and in those not submitted to radiotherapy (p=0.010). CONCLUSION: Adjuvant radiotherapy acted as a protective factor, reducing the risk of local recurrence in the gerenal cohort of phyllodes tumors and in the subgroup of malignant phyllodes tumors
 
WARNING - Viewing this document is conditioned on your acceptance of the following terms of use:
This document is only for private use for research and teaching activities. Reproduction for commercial use is forbidden. This rights cover the whole data about this document as well as its contents. Any uses or copies of this document in whole or in part must include the author's name.
AlineRochaDonato.pdf (4.28 Mbytes)
Publishing Date
2022-03-25
 
WARNING: Learn what derived works are clicking here.
All rights of the thesis/dissertation are from the authors
CeTI-SC/STI
Digital Library of Theses and Dissertations of USP. Copyright © 2001-2022. All rights reserved.