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Master's Dissertation
DOI
https://doi.org/10.11606/D.5.2022.tde-18042023-115238
Document
Author
Full name
Fernando Nivaldo de Oliveira
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2022
Supervisor
Committee
Costa, Silvia Figueiredo (President)
Dinardo, Carla Luana
Girão, Evelyne Santana
Santos, Daniel Wagner de Castro Lima
Title in Portuguese
Avaliação de arboviroses (Dengue, Zika vírus e Chikungunya) em doadores e receptores de transplante de células-tronco hematopoiéticas do HC-FMUSP
Keywords in Portuguese
Arbovírus
Chikungunya
Dengue
Transfusão
Transplante de células-tronco hematopoiéticas
Zika
Abstract in Portuguese
Nesta dissertação, dado ao fato do Brasil apresentar elevada prevalencia de arboviroses, especialmente Dengue (DENV), Zika (ZKV) e Chikungunya (CHKV) e possuirem a forma vetorial como sua principal transmissao, porém, podem ser transmitidas tambem associada a transfusao de produtos sanguineos, avaliou-se a transmissão destes agentes infecciosos por meio de transfusão sanguínea. Sabemos que a populacao de transplantados de celulas tronco-hematopoeticas (TCTH) esta frequentemente exposta a estes agentes infecciosos, seja pela necessidade frequente de transfusão de hemocomponentes, seja pela presenca vetorial endemica em nosso pais. Os resultados incluíram 93 pacientes durante o período realizado. A idade média foi de 52 anos e houve predominancia de individuos do sexo masculino (56,9%). Foram considerados 5 (5,3%) casos positivos por meio da sorologia na nossa amostra populacional. Todos estes decorreram de soroconversao. Nenhum caso apresentou RT-PCR positivo. Todos os hemocomponentes investigados apresentaram RT-PCR de arboviroses negativos, evidenciando baixa prevalência de transmissão transfusional destes agentes na nossa população estudada
Title in English
Evaluation of arbovirus (Dengue, Zika virus and Chikungunya) in donors and recipients of hematopoietic stem cell transplantation
Keywords in English
Arbovirus
Chikungunya
Dengue
Hematopoietic stem cell transplantation
Transfusion
Zika
Abstract in English
In this dissertation, given the fact that Brazil has a high prevalence of arboviruses, especially Dengue (DENV), Zika (ZKV) and Chikungunya (CHKV) and have the vector form as their main transmission, however, they can also be transmitted associated with the transfusion of blood products, the transmission of these infectious agents through blood transfusion was evaluated. We know that the hematopoietic stem cell (HSCT) transplant population is frequently exposed to these infectious agents, either because of the frequent need for blood components transfusion or because of the endemic vector presence in our country. The results included 93 patients during the period performed. The mean age was 52 years and there was a predominance of males (56.9%). Five (5.3%) cases were considered positive by serology in our population sample. All of these resulted from seroconversion. No case was RT-PCR positive. All investigated blood components showed negative RT-PCR of arboviruses, showing a low prevalence of transfusional transmission of these agents in our studied population
 
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Publishing Date
2023-05-05
 
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