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Doctoral Thesis
DOI
10.11606/T.5.2005.tde-07082006-101357
Document
Author
Full name
Carlos Baptista Barcaui
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2005
Supervisor
Committee
Sotto, Mirian Nacagami (President)
Casseb, Jorge Simão do Rosário
Duarte, Maria Irma Seixas
Landman, Gilles
Maceira, Juan Manuel Pineiro
Title in Portuguese
"Células-tronco foliculares na alopecia difusa não-cicatricial de pacientes HIV positivos"
Keywords in Portuguese
Alopecia
Células-tronco
Folículo piloso
HIV
Abstract in Portuguese
A alopecia difusa não-cicatricial (ADNC) acomete 7% dos pacientes HIV positivos. O objetivo deste trabalho foi comparar os achados histológicos e imunohistoquímicos (citoqueratina 19/TUNEL e caspase 3 clivada) em cortes transversais de couro cabeludo de 15 pacientes HIV-1 positivos com ADNC e de 12 controles sadios. A apoptose de células tronco-foliculares e amplificadoras transitórias na protuberância folicular foi demonstrada pela dupla marcação TUNEL/CK19 em 80% dos casos e em 25% dos controles e, pelo anticorpo anti-caspase 3 clivada em 61% dos casos e 16% dos controles. Não houve correlação entre a incidência de apoptose e o grau de imunodeficiência dentre os casos
Title in English
Hair follicle stem cells in diffuse non-cicatricial alopecia in HIV-1 positive patients
Keywords in English
Alopecia
Hair follicle
HIV
Stem cells
Abstract in English
Seven percent of HIV positive patients present diffuse non-cicatricial alopecia (DNCA). The aim of this study was to compare the histological and the immunohistochemical (cytokeratin 19/TUNEL and cleaved caspase 3) findings in transverse scalp sections of 15 HIV-1 positive patients with DNCA and 12 healthy controls. Follicular stem and transit amplifying cells apoptosis in the bulge was demonstrated by double labeling TUNEL/CK19 in 80% of cases and 25% of controls, and by the anti-cleaved caspase 3 antibody in 61% of cases and 16% of the controls. There was no relation between the incidence of apoptosis and the degree of immunodeficiency among cases
 
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Publishing Date
2006-08-08
 
WARNING: The material described below relates to works resulting from this thesis or dissertation. The contents of these works are the author's responsibility.
  • BARCAUI, Carlos Baptista, et al. Stem cell apoptosis in HIV-1 alopecia [doi:10.1111/j.1600-0560.2006.00517.x]. Journal of Cutaneous Pathology [online], 2006, vol. 33, n. 10, p. 667-671.
  • BARCAUI, Carlos Baptista, et al. Stem cell apoptosis in HIV-1 alopecia [doi:10.1111/j.1600-0560.2006.00517.x]. Journal of Cutaneous Pathology [online], 2006, vol. 33, p. 667-671.
  • SOTTO, M. N., BARCAUI, Carlos Baptista, e SILVA, A. M. G. Células tronco foliculares na alopecia difusa não-cicatricial de pacientes HIV-1 positivos. In XXIV Reunion Anual de Dermatológos Latinoamericanos, Buenos Aires, 2005. Resúmenes de trabajos científicos CD-ROM., 2005. Resumo.
All rights of the thesis/dissertation are from the authors
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