• JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  Bookmark and Share
Doctoral Thesis
Full name
Michel Nasser
Knowledge Area
Date of Defense
São Paulo, 2006
Wolosker, Nelson (President)
Castelli Junior, Valter
Cirino, Luis Marcelo Inaco
Neves, Rogerio Izar
Sitrângulo Junior, Cid José
Title in Portuguese
"Valor preditivo da trombomodulina sérica em pacientes com claudicação intermitente e com isquemia crítica de membros inferiores"
Keywords in Portuguese
Claudicação intermitente
Endotélio vascular
Extremidade inferior/patologia
Marcadores biológicos
Abstract in Portuguese
A Trombomodulina é um marcador endotelial da doença aterosclerótica, e seu uso como preditor da doença arterial obstrutiva periférica (DAOP) deve ser comprovada. Avaliou-se 41 pacientes com claudicação intermitente e 40 com isquemia crítica. A Trombomodulina plasmática (TMp) foi quantificada em todos os pacientes, através de método imunoenzimático (ELISA). As hipóteses de normalidade e de homogeneidade de variância foram provadas, respectivamente, pelos testes de Shapiro-Wilk e de Levene. A comparação da TMp entre ambos os grupos foi realizada empregando-se o teste t de Student. A utilização de pacientes com Claudicação Intermitente e com Isquemia Crítica é interessante como modelo de estudo e deve ser empregado para avaliar diferentes marcadores de prognóstico da DAOP. Não foi observada diferença estatisticamente significante nos níveis de TMp nos grupos, não permitindo utilizar-se a TMp para avaliar o prognóstico da doença arterial obstrutiva periférica (DAOP)
Title in English
Predictive value of the plasmatic levels of thrombomodulin in patients with intermittent claudication and critical ischemia in the lower limbs
Keywords in English
Biological markers
Endothelium vascular
Intermittent claudication
Lower extremity/pathology
Abstract in English
Thrombomodulin (TM) is an endothelial marker of arterosclerotic disease and its use as a predictor of Peripheral Arterial Disease (PAD) must be proven. Forty-one patients having intermittent claudication and forty having critical ischemia were evaluated. Plasmatic Thrombomodulin (TMp) was quantified in all patients using the immunoenzymatic method (ELISA). The hypotheses of normality and variance homogeneity were proven, respectively, using the Wilk-Shapiro and Levene Tests. The comparison of the TMp between both groups was carried out using the Student-T Test. The utilization of patients with Intermittent Claudication and Critical Ischemia is interesting as a study model and should be used to evaluate different prognostic markers of PAD. No statistically significant difference was observed in the TMp levels between the groups, thus not permitting the use of TMp to evaluate the prognostics of Peripheral Arterial Disease (PAD)
WARNING - Viewing this document is conditioned on your acceptance of the following terms of use:
This document is only for private use for research and teaching activities. Reproduction for commercial use is forbidden. This rights cover the whole data about this document as well as its contents. Any uses or copies of this document in whole or in part must include the author's name.
MichelNasser.pdf (2.23 Mbytes)
Publishing Date
WARNING: Learn what derived works are clicking here.
All rights of the thesis/dissertation are from the authors
Digital Library of Theses and Dissertations of USP. Copyright © 2001-2023. All rights reserved.