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Doctoral Thesis
DOI
10.11606/T.5.2010.tde-24052010-154013
Document
Author
Full name
Emmanuel Gomes Ciolac
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2010
Supervisor
Committee
Guimarães, Guilherme Veiga (President)
Andrade, Michele Schultz Ramos de
Curi, Tania Cristina Pithon
Serafin, José Alberto Neder
Vinagre, Carmen Guilherme Christiano de Matos
Title in Portuguese
Efeito do exercício aeróbico intervalado versus contínuo sobre o perfil hemodinâmico, metabólico e hormonal de mulheres jovens normotensas filhas de hipertensos
Keywords in Portuguese
Exercício
Função endotelial
Hipertensão
Insulina
Prevenção
Sistema nervoso simpático
Abstract in Portuguese
Histórico familiar de hipertensão está associado à anormalidades metabólicas e hemodinâmicas precoces. O exercício físico tem importante papel na prevenção e tratamento da hipertensão, mas as adaptações hemodinâmicas, metabólicas e hormonais em resposta ao treinamento físico não tem sido estudadas em indivíduos com histórico familiar de hipertensão. Nós comparamos os efeitos do treinamento com exercício intervalado (TI) e contínuo (CT) sobre variáveis hemodinâmicas, metabólicas e hormonais em normotensos filhos de hipertensos. Cinqüenta e nove mulheres saudáveis filhas de pais hipertensos, randomizadas para TI (n: 16; 24,4±3,8 anos), TC (n: 16; 26,6±4,9 years) ou grupo controle (CFH+; n: 12), e 15 mulheres jovens com pais normotensos tiveram a monitorização da pressão arterial ambulatorial (MAPA), velocidade de onda de pulso carótido-femoral (VOP), e bioquímica (colesterol total e frações, triglicérides, glicose, insulina e razão insulina/glicose) analisados antes e após 16 semanas de seguimento. Níveis de PA, nor-epinefrina (NE), endothelina-1 (ET-1) e nitrito/nitrato (NOx) também foram analisados durante um teste de esforço cardiopulmonar (TE). Treinamento físico foi realizado três vezes por semana durante 40 minutos à 65% do VO2PICO (TC) ou alternando 2 minutos à 55% com 1 minute à 85% VO2PICO (TI). MAPA, glicemia e níveis de colesterol foram similares entre os 4 grupos, mas os 3 grupos com histórico familiar positivo de hipertensão apresentaram maiores níveis de insulina e razão insulina/glicose, VOP, NE e ET-1, e menores níveis de NOx quando comparado com o grupo CFH-. Os dois tipos de exercício foram igualmente efetivos na melhora da MAPA, insulina e razão insulina/glicose; porém, TI foi mais efetivo para a melhora da VOP e condicionamento cardiorrespiratório, bem como para a melhora da resposta da PA, NE, ET-1 e NOx durante o TE. Após o seguimento, TI apresentou insulina e razão insulina/glicose, VOP, NE e ET-1 inferior e NOx superior ao de CFH+, enquanto apenas ET-1 do TC foi inferior à de CFH+. Concluindo, ambos os programas de treinamento melhoraram o perfil hemodinâmico, metabólico e hormonal de mulheres jovens normotensas filhas de hipertenso. Porém, o TI demonstrou-se mais efetivo para a melhora de algumas das variáveis analisadas. Estes achados podem ter importantes implicações para o desenho de programas exercício físico para a prevenção de hipertensão arterial hereditária.
Title in English
Effects of aerobic interval versus continuous aerobic exercise on hemodynamic, metabolic and hormonal profile in young normotensive women offspring of hypertensive parents
Keywords in English
Endothelial function
Exercise
Hypertension
Insulin
Nervous system sympathetic
Prevention
Abstract in English
Family history of hypertension is associated with early metabolic and hemodynamic abnormalities. Exercise training has an important role in the prevention and treatment of hypertension, but the hemodynamic, metabolic and hormonal adaptations to exercise training has not been studied in subjects with family history of hypertension. We compared the effects of aerobic interval (IT) and continuous exercise training (CT) on hemodynamic, metabolic and hormonal variables in offspring of hypertensive subjects. Fiftynine healthy women offspring of hypertensive subjects, randomized to IT (n: 16; 24.4±3.8 years), CT (n: 16; 26.6±4.9 years) or control group (CFH+; n: 12), and 15 young women with normotensive parents (CFH-) had their ambulatorial blood pressure (ABP), carotid-femoral pulse wave velocity (PWV), and biochemistry (total cholesterol and fractions, triglycerides, glucose, insulin and insulin-to-glucose ratio) analyzed before and after a 16- week follow-up. BP, nor-epinephrine (NE), endothelin-1 (ET-1) and nitrite/nitrate (NOx) levels were also analyzed during a graded exercise test (GXT). Exercise training was performed three times-a-week for 40 minutes at 65% of VO2PEAK (CT) or alternating 2 minutes at 55% with 1 minute at 85% VO2PEAK (IT). ABP, glucose and cholesterol levels were similar among all groups, but the 3 groups with positive family history of hypertension displayed increased insulin and insulin-to-glucose ratio, PWV, NE and ET-1, and decreased NOx when compared to CFH-. The 2 exercise groups were equally effective in improving ABP, insulin and insulin-to-glucose ratio; however, IT was superior to CT at improving PWV and cardiorespiratory fitness, as well as the BP, NE, ET-1 and NOx during the GXT. After the follow-up, IT group displayed insulin and insulin-to-glucose ratio, PWV, NE and ET-1 decreased and NOx increased than the CFH+, but only ET-1 was decreased in CT than CFH+. In conclusion, both exercise training programs improved hemodynamic, metabolic and hormonal profile in healthy young women offspring of hypertensive subjects. However, IT was more efficient for improving several of the analyzed variables. These findings may have important implications for exercise training programs for the prevention of an inherited hypertensive disorder.
 
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Publishing Date
2010-05-25
 
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  • CIOLAC, E G, et al. Haemodynamic, metabolic and neuro-humoral abnormalities in young normotensive women at high familial risk for hypertension [doi:10.1038/jhh.2010.21]. Journal of Human Hypertension [online], 2010, vol. 24, n. 12, p. 814-822.
  • CIOLAC, E. G., et al. Heart rate response to exercise and cardiorespiratory fitness of young women at high familial risk for hypertension : effects of interval vs continuous training [doi:10.1177/1741826711398426]. European Journal of Cardiovascular Prevention & Rehabilitation [online], 2011, vol. 18, n. 6, p. 824-830.
  • CIOLAC, Emmanuel G, et al. Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension [doi:10.1038/hr.2010.72]. Hypertension Research [online], 2010, vol. 33, n. 8, p. 836-843.
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