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Doctoral Thesis
DOI
https://doi.org/10.11606/T.5.2023.tde-20102023-134101
Document
Author
Full name
Guilherme Fernandes de Carvalho
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2023
Supervisor
Committee
Hueb, Whady Armindo (President)
Paola, Angelo Amato Vincenzo de
Ramires, Jose Antonio Franchini
Soares, Paulo Rogério
Title in Portuguese
Mortalidade associada com o número de artérias comprometidas e estratégias de tratamento em pacientes com doença arterial coronariana: estudo de longo prazo
Keywords in Portuguese
Anatomia coronariana
Angiografia
Doença da artéria coronariana
Mortalidade
Prognóstico
Revascularização miocárdica
Vasos coronários
Abstract in Portuguese
Introdução: Acredita-se que o número de artérias coronárias com lesões ateroscleróticas obstrutivas aumente o risco associado à doença arterial coronariana, levando a uma maior incidência de eventos cardíacos. No entanto, faltam dados conclusivos sobre a relação entre a extensão da aterosclerose coronariana e os desfechos clínicos. Métodos: trata-se de uma coorte retrospectiva, observacional, unicêntrica a qual incluiu pacientes com doença arterial coronariana estável e função ventricular esquerda preservada que eram elegíveis para qualquer uma das estratégias terapêuticas (tratamento clínico, percutâneo ou cirúrgico), incluídos no Registro MASS. Os pacientes foram estratificados de acordo com o número de artérias com lesões obstrutivas e, posteriormente, de acordo com a estratégia de tratamento inicialmente adotada. O desfecho primário foi mortalidade por qualquer causa. Os desfechos secundários incluíram um desfecho composto de morte por qualquer causa, infarto do miocárdio não fatal e necessidade de reintervenção coronariana, bem como os componentes individuais do desfecho composto. Resultados: Entre maio de 1988 e janeiro de 2018, 2.000 pacientes foram incluídos no banco de dados MASS. Desses, 1.855 pacientes foram incluídos nesta análise e acompanhados por 5 anos. Entre eles, 224 (12%) tinham doença uniarterial (SVD), 536 (29%) tinham doença biarterial (2VD) e 1.095 (59%) tinham doença triarterial (3VD). A mortalidade por qualquer causa para SVD, 2VD e 3VD foi de 14 (6,3%), 57 (10,6%) e 115 (10,5%), respectivamente (p = 0,054). Não houve diferença estatisticamente significante entre os desfechos secundários (p = 0,2). Resultados semelhantes foram encontrados após estratificação adicional de acordo com a estratégia de tratamento inicial. Conclusão: Não houve associação entre a maior gravidade angiográfica da doença coronariana e a mortalidade entre pacientes com uma, duas ou três artérias coronárias epicárdicas com lesões obstrutivas
Title in English
Mortality associated with the number of diseased vessels and therapeutic strategies for coronary artery disease: long-term follow-up
Keywords in English
Anatomy coronary
Angiography
Coronary artery disease
Coronary vessels
Mortality
Myocardial revascularization
Prognosis
Abstract in English
Introduction: It is admitted that the number of diseased coronary arteries has an adverse impact on the prognosis of coronary artery disease, leading to a higher incidence of cardiac events. However, conclusive data on the association between the extent of coronary atherosclerosis and outcomes are not conclusive. Methods: This retrospective, single-center, observational cohort study included patients with stable coronary artery disease and preserved ventricular function who were eligible to any of the three therapeutic strategies (medical, angioplasty, or surgery) included in the MASS-Trials database. Patients were stratified according to the number of diseased arteries and subsequently according to the initial treatment strategy. The primary endpoint was overall mortality. Secondary endpoints included the composite of all-cause death, nonfatal myocardial infarction, and need for reintervention, as well as the individual components of the composite endpoint. Results: Between May 1988 and January 2018, 2,000 patients who met the inclusion criteria in the MASS-Trials database were included. Of these, 1,855 patients were enrolled and followed for 5 years. Among them, 224 (12%) had single-vessel disease (SVD), 536 (29%) had double-vessel disease (2VD), and 1,095 (59%) had triple-vessel disease (3VD). All-cause mortality for SVD, 2VD, and 3VD was 14 (6.3%), 57 (10.6%), and 115 (10.5%), respectively (p = 0.054). There was no statistically significant difference observed for the secondary endpoints as well (p = 0.2). Similar results were found upon further stratification according to the initial treatment strategy. Conclusion: Overall survival was similar regardless of the number of diseased arteries. There was no association of the initial treatment strategy with mortality
 
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Publishing Date
2023-11-08
 
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