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Doctoral Thesis
DOI
10.11606/T.5.2004.tde-09082005-113017
Document
Author
Full name
Áurea Jacob Chaves
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2004
Supervisor
Committee
Sousa, Amanda Guerra de Moraes Rego (President)
Coelho, Otavio Rizzi
Lima, Valter Correia
Marin Neto, Jose Antonio
Martinez Filho, Eulogio Emilio
Title in Portuguese
"Análise volumétrica da hiperplasia intimal intra-stent em pacientes diabéticos tratados com e sem abciximab"
Keywords in Portuguese
CONTENEDORES/efeitos adversos
CORONARIOPATIA/ultrasonografia
DIABETES MELLITUS/etiologia
GLICOPROTEÍNAS/antagonistas & inibidores
IMPLANTE DE PRÓTESE VASCULAR/métodos
INIBIDORES DA AGREGAÇÃO DE PLAQUETAS/análise
Abstract in Portuguese
Noventa e seis pacientes com diabetes melito do tipo 2 foram randomizados para receberem ou não abciximab durante o implante eletivo de stent coronário, com o objetivo de determinar se esse inibidor da glicoproteína IIb/IIIa reduz a hiperplasia intimal intra-stent, avaliada pelo ultra-som intracoronário, aos seis meses de evolução. A análise volumétrica mostrou que o abciximab não reduz o volume de obstrução intra-stent nestes pacientes [41,3% (DP21,0%) versus 40,5% (DP18,3%), p=0,853].
Title in English
Volumetric analysis of in-stent intimal hyperplasia in diabetic patients treated with or without abciximab
Keywords in English
BLOOD VESSEL PROSTHESIS IMPLANTATION/methods
CORONARY DISEASE/ultrasonography
DIABETES MELLITUS/etiology
GLYCOPROTEINS/antagonists & inhibitors
PLATELET AGGREGATION INHIBITORS/analysis
STENTS/adverse effects
Abstract in English
Ninety-six type 2 diabetics were randomly assigned to receive abciximab or no abciximab at the time of elective stent implantation to determine whether this IIb/IIIa glycoprotein inhibitor would reduce in-stent intimal hyperplasia, measured by intravascular ultrasound, at 6-month follow-up. Volumetric analysis showed that abciximab was not associated with a reduction of in-stent volume obstruction in diabetic patients [41.3% (DP21.0%) versus 40.5% (DP18.3%), p=0.853).
 
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AureaJacobChaves.pdf (2.66 Mbytes)
Publishing Date
2005-08-09
 
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