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Doctoral Thesis
DOI
10.11606/T.46.2014.tde-20012015-142051
Document
Author
Full name
Suélen Harumi Takahashi
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2014
Supervisor
Committee
Torresi, Susana Ines Cordoba de (President)
Alves, Wendel Andrade
Longo, Claudia
Petri, Denise Freitas Siqueira
Vichi, Flavio Maron
Title in Portuguese
Desenvolvimento de hidrogéis inteligentes como meio de liberação controlada de fármaco
Keywords in Portuguese
Ácido acrílico
Eletroquímica
Hidrogel
Liberação controlada
Multi-estímulo
Polímero condutor
Polipirrol
Abstract in Portuguese
O objetivo principal deste trabalho foi a formação de um material que possa responder aos estímulos pH e elétrico na liberação controlada de fármaco. Assim, hidrogéis condutores foram obtidos pela combinação do hidrogel de ácido acrílico com o polímero condutor polipirrol. O polipirrol foi eletroquimicamente polimerizado no interior do hidrogel e o material obtido (AA-PPi) conservou a propriedade de intumescimento que é característico dos hidrogéis e a eletroatividade, dos polímeros condutores. Além disso, o grau de intumescimento variou com a força iônica e pH. A liberação da safranina pelo hidrogel de AA-PPi foi estudada combinando os estímulos de pH e potencial e o resultado mais interessante foi a obtenção do perfil cuja velocidade de liberação foi constante, indicando uma cinética de ordem zero. Liberação do tipo liga-desliga foi estudada com o intuito de verificar se o AA-PPi pode ser controlado por pH e/ou potencial elétrico. Foi observado que dependendo da combinação de pH e potencial, o hidrogel pode ser controlado, por variação de pH ou de potencial elétrico. Outro hidrogel sintetizado foi o do hidrogel de AA contendo o poli(3,4-etilenodioxitiofeno):poli(estireno sulfonado), este por sua vez foi polimerizado quimicamente. Porém os resultados preliminares indicaram incompatibilidade entre os dois polímeros
Title in English
Development of smart hydrogels as controlled drug delivery systems
Keywords in English
Acrylic acid
Conducting polymer
Controlled drug delivery
Electrochemistry
Hydrogel
Multi-stimuli
Polypyrrole
Abstract in English
The aim of this work was to obtain a material that can respond to both pH and potential stimuli for drug release. Thus, eletroactive hydrogels were synthesized by the combination of the properties of acrylic acid hydrogels with the conducting polymer polypyrrole. The polypyrrole was electrochemically polymerized into the hydrogel (AA-PPi), and the material retained the swelling properties that is characteristic of hydrogels and electroactivity of conducting polymers. Furthermore, the degree of swelling varied with the ionic strength and pH. The safranin release by AA-PPi was mensured under the combination of pH and potential stimuli and the most interesting result was obtained from the linear profile indicating a zero-order kinetics. On-off release profile was studied in order to verify if the AA-PPi can be controled by pH and/or electric potential. Depending on the combination of pH or electrochemical potential, the hydrogel had pH or electrochemical control. Other hydrogel synthesized was from AA hydrogel containing poly(3,4- ethylenedioxythiophene):polystyrene sulfonate, this, in other hand, was chemically polymerized. However, preliminary results indicate incompatibility between the two polymers
 
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Publishing Date
2015-02-13
 
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