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Doctoral Thesis
DOI
10.11606/T.42.2013.tde-20092013-095552
Document
Author
Full name
Rafael Peres
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2013
Supervisor
Committee
Cipolla Neto, Jose (President)
Gorab, Eduardo
Iannini, Carlos Arturo Navas
Marques, Antonio Carlos
Morandini, André Carrara
Title in Portuguese
Estudo da presença, da função e das vias de produção da melatonina em invertebrados.
Keywords in Portuguese
Cronobiologia
Glândula pineal
Invertebrados marinhos
Melatonina
Abstract in Portuguese
O tecido adiposo, através da leptina, desempenha um papel permissivo sobre a maturação sexual do indivíduo. Apesar da importância do tecido adiposo para a puberdade, pouco se sabe a respeito do processo de formação deste tecido neste período da vida. Estudos em humanos têm descrito a presença de resistência à insulina puberal. Assim, frente à importância do tecido adiposo para a puberdade, o objetivo do trabalho foi investigar a resposta do tecido adiposo à insulina no período puberal. Foram utilizados os coxins adiposos subcutâneo e periepididimal. Na puberdade, paralelamente à intolerância à glicose transitória que ocorreu nas semanas iniciais, e, portanto, prejuízo da utilização da glicose pelos tecidos insulino-dependentes, o tecido adiposo (SC e PE) teve sua responsividade normal à insulina e uma melhor capacidade de incorporação de glicose em lipídeos o que leva a crer que há um desvio da utilização deste substrato energético, a glicose, para a formação do tecido adiposo.
Title in English
Melatonin in invertebrates: presence, functions and production pathways.
Keywords in English
Chronobiology
Marine invertebrates
Melatonin
Pineal gland
Abstract in English
The adipose tissue is critical to puberty. Leptin exerts a permissive role to hypothalamic-hypophysial-gonadal maturation and, thereby, adipose tissue is necessary to pubertal development. Despite its importance to puberty, little is known about the process of adipose tissue formation during this period of life. Researches have described insulin resistance at pubertal period in humans. The adipose tissue importance to puberty added to pubertal insulin resistance described in humans lead us to investigate how the adipose tissue responds to insulin at this period since it is essential at this time. We assessed two distinct fat pads: the subcutaneous fat pad and the epididymal one. At the puberty, despite the temporary glucose intolerance and the constraint for glucose utilization by insulin-dependent tissues, the adipose tissue had normal insulin responsiveness plus an improved capacity to synthesize lipids from glucose which led us to hypothesize that glucose could have been deviated towards the adipose tissue.
 
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Publishing Date
2013-12-05
 
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