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Doctoral Thesis
DOI
10.11606/T.42.2014.tde-19112014-133201
Document
Author
Full name
Gustavo Santos Masson
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2014
Supervisor
Committee
Michelini, Lisete Compagno (President)
Britto, Luiz Roberto Giorgetti de
Brum, Patricia Chakur
Campos Junior, Ruy Ribeiro de
Laurindo, Francisco Rafael Martins
Title in Portuguese
Treinamento aeróbio x disfunção autonômica na hipertensão espontânea: uma abordagem molecular em núcleos centrais de regulação.
Keywords in Portuguese
Barorreflexo
Estresse oxidativo
Hipertensão Arterial
Inflamação
Microglia ativada
Núcleo paraventricular do hipotálamo
Sistema nervoso central
Treinamento aeróbio
Abstract in Portuguese
Disfunção autonômica, inflamação e estresse oxidativo são características da hipertensão. Investigamos a cronologia das adaptações fisiológicas e celulares induzidas pelo treinamento aeróbio em ratos espontaneamente hipertensos (SHR). SHR exibiam disfunção autonômica e, no núcleo Paraventricular no hipotálamo (PVN), estresse oxidativo e inflamação. Duas semanas de treinamento aeróbio normalizaram a função autonômica, estresse oxidativo, inflamação, ativação de microglia e conteúdo de HMGB no PVN. Após 8 semanas, SHR treinados apresentaram menor pressão arterial e resistência vascular periférica. Redução do conteúdo de HMGB1 consiste num mecanismo para explicar os benefícios do treinamento, já que infusão aguda intracerebroventricular de HMGB1 produziu disfunção autonômica e ativação de microglia pela sinalização do CxCr4. Assim, redução do estresse oxidativo e da inflamação induzida pelo treinamento contribui para a reversão da disfunção autonômica na hipertensão e a redução da liberação de HMGB1 explica estes benefícios.
Title in English
Aerobic training vs autoniomic dysfunction in spontaneous hypertension: a molecular approach in the autonomic control areas.
Keywords in English
Activated microglia
Arobic training
Baroreflex
Central nervous system
Hypertension
Hypothalamic paraventricular nucleus
Inflammation
Oxidative stress
Abstract in English
Autonomic dysfunction, inflammation and oxidative stress are hallmarks in hypertension. We evaluated time-course of physiologic and cellular adaptations induced by aerobic training in spontaneous hypertensive rat (SHR). SHR showed autonomic dysfunction and, in the hypothalamic paraventricular nucleus (PVN), oxidative stress and inflammation. 2-weeks of aerobic training normalized autonomic function, oxidative stress, inflammation, microglia activation and HMGB1 content into the PVN. After 8-weeks, trained SHR exhibited lower arterial pressure and peripheral vascular resistance. Decrease of HMGB1 content is a mechanism to explain these training benefits, since HMGB1 intracerebroventricular acute infusion induced autonomic dysfunction, microglia activation through CxCr4 signaling. So, decrease of oxidative stress and inflammation induced by aerobic training contributes to reverse autonomic dysfunction in hypertension and decrease of HMGB1 content explains these benefits.
 
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Release Date
2016-11-26
Publishing Date
2014-11-27
 
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