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Master's Dissertation
DOI
10.11606/D.42.2007.tde-19102007-122123
Document
Author
Full name
Katia Burgi
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2007
Supervisor
Committee
Michelini, Lisete Compagno (President)
Campos Junior, Ruy Ribeiro de
D'Avila, Kátia de Angelis Lobo
Title in Portuguese
Tirosina hidroxilase como marcador da atividade simpática em artérias musculares esqueléticas e renais de ratos normotensos: efeitos do treinamento fisico.
Keywords in Portuguese
Arteríolas
Normotenso
Sistema nervoso simpático
Tirosina Hidroxilase
Treinamento físico
WKY
Abstract in Portuguese
Apesar de não alterar a pressão de normotensos, o treinamento físico (T) promove importantes ajustes periféricos e adapatações centrais do controle cardiovascular mediados pelo vago e simpático. Neste trabalho investigamos os efeitos do T (55% da capacidade máxima) sobre a inervação simpática vascular para os territórios muscular esquelético (locomotor e não locomotor) e renal e adrenais, através de imunohistoquimica e Western Blot para Tirosina-Hidroxilase (TH). T aumentou a capacidade física (+0,07±0,06 Km/h) e reduziu a FC (de 327±7 para 308±10 bpm), sem alterar a PA (126mmHg) e a estrutura de arteriolas dos diferentes territórios. T também determinou redução na imunoreatividade para TH nos músculos locomotores (-48%, p<0,05), sem alterações nos não locomotores e rins. A noradrenalina na artéria femoral (HPLC) encontrava-se reduzida após T. Nenhuma alteração foi detectada nas catecolaminas adrenais.Os dados indicam, que o T não altera as catecolaminas plasmáticas, mas reduz a atividade simpática vascular em normotensos, sendo este efeito tecido-específico.
Title in English
Tirosyne hydroxilase as a marker of sympathetic drive within skeletal muscle and renal arterioles of normotensive rats: effects of physical training.
Keywords in English
Arterioles
Exercise training
Normotensive
Sympathetic nervous system
Tirosyne hydroxilase
WKY
Abstract in English
Exercise training (T) does not reduce pressure in normotensive, but causes peripheral and central adjustments on cardiovascular system, mediated by autonomic nervous system. In this study we investigated whether T (55% maximal exercise capacity) is able to change vascular sympathetic drive to skeletal muscle (locomotor, non-locomotor), kidney and adrenals, using immunohistochemistry and western blot for tyrosine hydroxylase (TH). T improved performance (+0,07±0,06 Km/h) and reduced resting HR (from 327±7 to 308±10 bpm) without changing MAP (126mmHg) and arterioles wall/ lumen ratio in any tissue. T caused 48% decrease on TH-immunoreactivity of exercised muscles arterioles, without changes on non-exercised tissues. Norepinephrine concentration on femoral arteries was reduced after T. There was no change on adrenal. TH content. Decreased sympathetic drive to skeletal muscles arterioles (without changes on plasma cathecolamines) is a beneficial, tissue-specific effect in normotensive individuals.
 
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Publishing Date
2007-10-24
 
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