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Thèse de Doctorat
DOI
10.11606/T.42.2008.tde-16092008-115901
Document
Auteur
Nom complet
Paula Eichler
Unité de l'USP
Domain de Connaissance
Date de Soutenance
Editeur
São Paulo, 2008
Directeur
Jury
Machado, Ubiratan Fabres (Président)
Anhê, Gabriel Forato
Caperuto, Luciana Chagas
Giannella, Maria Lucia Cardillo Correa
Mori, Rosana Cristina Tieko
Titre en portugais
Diminuição da proteína GLUT4 em tecido adiposo de ratos tratados com injeções subcutâneas de óleos de soja ou de girassol.
Mots-clés en portugais
Biologia
Fisiologia
Metabolismo
Metabolismo de carbohidrato
Metabolismo energético
Resumé en portugais
Tratamos ratos por 7 dias com injeções subcutâneas de óleos de soja (S) ou de girassol (G). Verificamos o desenvolvimento de resistência insulínica, com diminuição de GLUT4 e de sua translocação no tecido adiposo de ratos tratados com estes óleos, apesar de aumento no RNAm de GLUT4 no músculo e no tecido adiposo. O tratamento com girassol diminuiu RNAm de GLUT1 no adiposo, onde também diminuiu a quantidade de RNAm de NF-kB. (outros fatores transcricionais não apresentaram alteração: PPARg, MEF2A e MF2D). Dosamos ácidos graxos no plasma, fígado (sem alterações), músculo (palmitoléico aumentou no grupo G; linolênico diminuiu no S e G e araquidônico aumentou no S) e adiposo (palmítico e esteárico aumentaram e linoleico diminuiu nos grupos S e G, além de aumentar a proporção saturados/ insaturados).
Titre en anglais
Decrease in GLUT4 protein in adipose tissue of rats treated with subcutaneous injections of soybean or sunflower oils.
Mots-clés en anglais
Biology
Carbohidrate metabolism
Energetic metabolism
Metabolism
Physiology
Resumé en anglais
We treated rats for 7 days with subcutaneous soybean (SB) oil or sunflower (SF)oil injections. Insulin resistance was developed, with a decrease in GLUT4 quantity and translocation in adipose tissue in the rats treated with those oils, despite GLUT4 mRNA increase in muscle and adipose tissue. Sunflower treatment led to decrease in GLUT1mRNA in adipose tissue, where NF- kB mRNA was also decreased (other transcriptional factors did not change: PPARg, MEF2A e MF2D). Fatty acids were measured in the plasma, the liver (no changes), muscle (palmitoleic increased in SF, linolenic decreased in SB and SF and arachidonic increased in SB) and adipose tissue (palmitic and stearic increased and linoleico decreased in SB and SF, besides increasing in saturated/ unsaturated ratio.
 
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Date de Publication
2008-10-03
 
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Centro de Informática de São Carlos
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