• JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
 
  Bookmark and Share
 
 
Doctoral Thesis
DOI
10.11606/T.42.2008.tde-16092008-115901
Document
Author
Full name
Paula Eichler
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2008
Supervisor
Committee
Machado, Ubiratan Fabres (President)
Anhê, Gabriel Forato
Caperuto, Luciana Chagas
Giannella, Maria Lucia Cardillo Correa
Mori, Rosana Cristina Tieko
Title in Portuguese
Diminuição da proteína GLUT4 em tecido adiposo de ratos tratados com injeções subcutâneas de óleos de soja ou de girassol.
Keywords in Portuguese
Biologia
Fisiologia
Metabolismo
Metabolismo de carbohidrato
Metabolismo energético
Abstract in Portuguese
Tratamos ratos por 7 dias com injeções subcutâneas de óleos de soja (S) ou de girassol (G). Verificamos o desenvolvimento de resistência insulínica, com diminuição de GLUT4 e de sua translocação no tecido adiposo de ratos tratados com estes óleos, apesar de aumento no RNAm de GLUT4 no músculo e no tecido adiposo. O tratamento com girassol diminuiu RNAm de GLUT1 no adiposo, onde também diminuiu a quantidade de RNAm de NF-kB. (outros fatores transcricionais não apresentaram alteração: PPARg, MEF2A e MF2D). Dosamos ácidos graxos no plasma, fígado (sem alterações), músculo (palmitoléico aumentou no grupo G; linolênico diminuiu no S e G e araquidônico aumentou no S) e adiposo (palmítico e esteárico aumentaram e linoleico diminuiu nos grupos S e G, além de aumentar a proporção saturados/ insaturados).
Title in English
Decrease in GLUT4 protein in adipose tissue of rats treated with subcutaneous injections of soybean or sunflower oils.
Keywords in English
Biology
Carbohidrate metabolism
Energetic metabolism
Metabolism
Physiology
Abstract in English
We treated rats for 7 days with subcutaneous soybean (SB) oil or sunflower (SF)oil injections. Insulin resistance was developed, with a decrease in GLUT4 quantity and translocation in adipose tissue in the rats treated with those oils, despite GLUT4 mRNA increase in muscle and adipose tissue. Sunflower treatment led to decrease in GLUT1mRNA in adipose tissue, where NF- kB mRNA was also decreased (other transcriptional factors did not change: PPARg, MEF2A e MF2D). Fatty acids were measured in the plasma, the liver (no changes), muscle (palmitoleic increased in SF, linolenic decreased in SB and SF and arachidonic increased in SB) and adipose tissue (palmitic and stearic increased and linoleico decreased in SB and SF, besides increasing in saturated/ unsaturated ratio.
 
WARNING - Viewing this document is conditioned on your acceptance of the following terms of use:
This document is only for private use for research and teaching activities. Reproduction for commercial use is forbidden. This rights cover the whole data about this document as well as its contents. Any uses or copies of this document in whole or in part must include the author's name.
Publishing Date
2008-10-03
 
WARNING: Learn what derived works are clicking here.
All rights of the thesis/dissertation are from the authors
Centro de Informática de São Carlos
Digital Library of Theses and Dissertations of USP. Copyright © 2001-2021. All rights reserved.