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Master's Dissertation
Full name
Amanda Baron Campaña
Knowledge Area
Date of Defense
São Paulo, 2008
Lima, Fabio Bessa (President)
Dolnikoff, Miriam Sterman
Sannomiya, Paulina
Title in Portuguese
A intolerância à glicose que se instala precocemente em ratos retarda o desenvolvimento puberal e desregula o metabolismo lipídico e glicídico.
Keywords in Portuguese
Desenvolvimento genital puberal
Intolerância a glicose
Lipogênese e Lipólise
Metabolismo de glicose
Resistência a insulina
Tecido adiposo branco
Abstract in Portuguese
A crescente prevalência de diabetes mellitus (DM) em nível mundial, a sua incidência cada vez maior em crianças e adolescentes e resultados prévios obtidos em nosso laboratório (piora do quadro diabético em ratos na puberdade) nos levaram a investigar o metabolismo de glicose em tecido adiposo branco na puberdade em ratos controle (CO) e intolerantes à glicose (STZ). Parâmetros de desenvolvimento corporal e maturação sexual foram estudados entre a 5ª e a 10ª semanas de vida dos animais, identificando-se a 6ª e 7ª semanas como importante fase da puberdade. Desta forma, os estudos metabólicos foram realizados neste período. Os animais CO apresentaram franca resistência à insulina no período da puberdade, com prejuízos no metabolismo de glicose em adipócitos isolados. A injeção de estreptozotocina no quinto dia de vida produziu um quadro de intolerância à glicose em nossos animais, resultando em atraso no início do estirão de crescimento e desenvolvimento sexual. A resistência fisiológica à insulina da puberdade não produziu piora da resposta à insulina no tecido adiposo branco.
Title in English
The glucose intolerance that is manifested early in the life in rats retards pubertal development and derranges carbohydrate and lipid metabolism.
Keywords in English
Glicose intolerance
Glicose metabolism
Insulin resistance
Lipogenesis and Lipolysis
Pubertal development
White adiposo tissue
Abstract in English
The growth in the prevalence of diabetes mellitus (DM), a larger incidence of type 1 and 2 DM in children and adolescents and the previous results of our laboratory (worsening of the metabolic picture in diabetic rats during puberty) motivate us to study the glucose metabolism in the puberty in order to assess the possible influence of the physiological insulin resistance characteristic of this period on the course of the diabetic status. Five-day old male Wistar rats were divided into two experimental groups: control group (CO) and streptozotocin group (STZ). Body development and sexual maturation were weekly evaluated between the 5th and 10th weeks of life. We identify the 6th and 7th weeks as an important early phase of the puberty. The insulin resistance and a slight degree of glucose intolerance were determined in non-diabetic rats. On the other hand, STZ group showed insulin resistance and it was impaired in the course of puberty suggesting that the developing of this resistance during the puberty presents a different characteristic of that seen in normal rats.
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