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Master's Dissertation
DOI
10.11606/D.42.2008.tde-16032009-153306
Document
Author
Full name
Mário Alves de Siqueira Filho
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2008
Supervisor
Committee
Carvalho, Carla Roberta de Oliveira (President)
Akamine, Eliana Hiromi
Liberti, Edson Aparecido
Title in Portuguese
Músculo esquelético e envelhecimento: vias de sinalização da insulina e IGF 1 nos diferentes tipos de fibras musculares, perfil morfológico e efeito do DHEA em ratos apresentando sarcopenia.
Keywords in Portuguese
Desidroepiandrosterona (DHEA)
Envelhecimento
Insulina
Músculo esquelético
Sarcopenia
Tipos de fibra
Abstract in Portuguese
Com o envelhecimento observa-se redução da massa muscular, aumento da resistência à insulina e queda nos níveis séricos de alguns hormônios, entre eles o DHEA. Ratos com 12-14 meses de idade apresentam regulação músculo-específica em vias da insulina e IGF 1 em músculos com populações distintas de tipos de fibras e como indicador de sarcopenia apresentam redução da proporção e tamanho de fibras tipo 2b. Dose única de DHEA não modula as vias da insulina e IGF 1 no músculo esquelético e reduz tamanho de fibras tipo 1 no EDL.
Title in English
Skeletal muscle and insulin action: intracellular pathway in type 1 and type 2 muscle fibers, morphological pattern, and effect of DHEA in sarcopenic rats.
Keywords in English
Aging
Dehydroepiandrosterone (DHEA)
Fiber types
Insulin
Sarcopenia
Skeletal muscle
Abstract in English
Reductions in skeletal muscle mass, increased insulin resistance, and decrements in several hormones serum levels, including DHEA, are features observed in aging. Twelve to fourteen months old rats present specific regulation in the insulin and the IGF-1 intracellular pathway in distinct skeletal muscle fiber composition and show reductions in size and proportion of muscle composed predominantly by fiber type 2. DHEA treatment had no effect in these intracellular pathways but induces reduction in the size of type 1 fiber in the EDL muscle.
 
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Publishing Date
2009-03-23
 
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