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Doctoral Thesis
DOI
10.11606/T.42.2016.tde-09112016-144856
Document
Author
Full name
Leila Buttler
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2016
Supervisor
Committee
Michelini, Lisete Compagno (President)
Campos Junior, Ruy Ribeiro de
Canteras, Newton Sabino
Oliveira, Edilamar Menezes de
Torrão, Andréa da Silva
Title in Portuguese
A disfunção da barreira hematoencefálica em SHR é normalizada pelo treinamento aeróbio de baixa a moderada intensidade.
Keywords in Portuguese
Angiotensina II
Barreira hematoencefálica
Hipertensão
Modulação autonômica
Treinamento aeróbio
Abstract in Portuguese
A hipertensão cursa com importante déficit autonômico e lesão da barreira hematoencefálica (BHE) enquanto que o treinamento aeróbio (T) de hipertensos reduz acentuadamente a lesão da BHE, mantendo sua integridade no PVN, NTS e RVLM mesmo na persistência de níveis pressóricos elevados. Esta rápida resposta ao T (2 semanas) é condicionada pela redução da disponibilidade de ANGII nas áreas encefálicas, simultâneo aumento da expressão de podócitos dos astrócitos e desativação da microglia, os quais ocorrem simultaneamente à redução do simpático vasomotor (2 semanas) e antes mesmo do aumento da variabilidade da frequência cardíaca, da atividade parassimpática ao coração, da instalação da bradicardia de repouso e queda parcial da pressão arterial, que se instalam a partir da 4ª semana de T. Alterações na permeabilidade da BHE de hipertensos (lesão com prejuízo estrutural/funcional) e treinados (manutenção da integridade estrutural/funcional) são importantes fatores a condicionar respectivamente a disfunção autonômica na hipertensão ou a sua correção pelo treinamento.
Title in English
Blood brain barrier dysfunction in SHR is normalized by low to moderate intensity exercise training.
Keywords in English
Aerobic training
Angiotensin II
Autonomic modulation
Blood brain barrier
Hypertension
Abstract in English
The arterial hypertension is accompanied by important autonomic dysfunction and blood-brain barrier (BBB) lesion while aerobic training (T) in hypertension strongly decreases the BBB lesion, maintaining its integrity on the PVN, NTS and RVLM even in the persistence of high blood pressure (BP) levels. This early response to T (2 weeks) is conditioned by the reduction of ANGII availability, increased expression of astrocytic podocytes and deactivation of the microglia in brain areas. These responses occurred simultaneously with the reduction of vasomotor sympathetic activity (2 weeks) and before the increase of both heart rate variability and parasympathetic activity, resting bradycardia and partial BP fall, appearing only at the 4th week. Changes on the BBB permeability in hypertension (lesion with structural/functional damage) and trained (maintenance of the structural/ functional integrity) are important factors to condition the autonomic dysfunction in hypertension or its correction by the training, respectively.
 
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Release Date
2018-11-09
Publishing Date
2016-11-09
 
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