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Master's Dissertation
DOI
10.11606/D.42.2015.tde-07122015-190150
Document
Author
Full name
Raul Henrique Oliveira Pinheiro
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2015
Supervisor
Committee
Michelini, Lisete Compagno (President)
Brum, Patricia Chakur
Lacchini, Silvia
Title in Portuguese
Evolução temporal da pressão arterial e de alterações vasculares em SHR jovens durante o estabelecimento da hipertensão: o efeito do treinamento.
Keywords in Portuguese
Colágeno
Controle autonômico
Fase pré-hipertensiva
Hipertensão
Pressão arterial
Remodelamento vascular
Treinamento aeróbio
Abstract in Portuguese
Estudos na fase crônica da hipertensão comprovam a eficácia do treinamento aeróbio (T) em reduzir parcialmente a pressão arterial (PA), no qual correlacionavam-se com o remodelamento vascular. Pouco se sabe sobre o potencial efeito benéfico do T iniciado em fase pré-hipertensiva. Os objetivos foram analisar em SHR jovens (4 semanas) e seus controles WKY os efeitos sequenciais do T sobre níveis de PA, alterações vasculares, conteúdo de colágeno total, associando-as à modulação neural. Animais em fase pré-hipertensiva realizaram T de baixa intensidade (50-60%) ou sedentarismo por 8 semanas. Foram avaliados os parâmetros funcionais e seus componentes espectrais, alterações estruturais ocorridas em artérias (femoral e renal), arteríolas (músculo sóleo e temporal) e com conteúdo de colágeno. O T reduziu a PAM no SHR na 4ª e 8ª semana, provocou bradicardia de repouso em ambos os grupos na 8ª, melhorou a variabilidade da FC (WKY e SHR) e impediu o aumento da variabilidade da PAS nos SHR. Hipertensão provocou aumento da razão parede/luz e conteúdo de colágeno em ambas as artérias, T impediu esse aumento na artéria femoral, efeito não foi observado na artéria renal. T impediu a queda da razão parede/luz em arteríolas do músculo sóleo sem efeitos no músculo sóleo.
Title in English
Time-course changes of blood pressure and vascular remodeling in young shr during the stablishment of hypertension: effects of low intensity aerobic training.
Keywords in English
Aerobic training
Arterial pressure
Autonomic control
Collagen
Hypertension
Pre-hypertensive phase
Vascular remodeling
Abstract in English
Studies in the chronic phase of hypertension prove the effectiveness of aerobic training (T) in partially reduce blood pressure (BP), which correlated with vascular remodeling. Little is known about the potential beneficial effect of T started in pre-hypertensive stage. The objectives were to analyze in young SHR (4 weeks) and their WKY controls the sequential effects of T on BP levels, vascular changes, total collagen content, linking them to the neural modulation. Animals in the pre-hypertension stage T made of low intensity (50-60%) or inactivity for 8 weeks. We evaluated the functional parameters and their spectral components, structural changes in arteries (femoral and renal), arterioles (soleus muscle and temporal) and collagen content. OT reduced MAP in SHR at 4 and 8 weeks, caused bradycardia standby in both groups in 8th improved HR variability (WKY and SHR) and prevent the increase of SBP variability in SHR. Hypertension caused ratio increase / wall light and collagen content in both arteries, t prevented this increase in femoral artery, an effect was not observed in the renal artery. T prevented the fall of reason / wall light in arterioles of the soleus muscle without effects in the soleus muscle.
 
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Release Date
2017-12-06
Publishing Date
2015-12-07
 
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