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Doctoral Thesis
DOI
10.11606/T.42.2014.tde-12122014-092623
Document
Author
Full name
Beatriz Golegã Accetturi
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2014
Supervisor
Committee
Lima, Wothan Tavares de (President)
Martins, Joilson de Oliveira
Munhoz, Carolina Demarchi
Souza, Heraldo Possolo de
Tibério, Iolanda de Fátima Lopes Calvo
Title in Portuguese
Avaliação do papel dos hormônios sexuais femininos em modelo murino de asma experimental.
Keywords in Portuguese
Asma
Camundongos
Hormônios sexuais femininos
Mecânica pulmonar
Reatividade das vias aéreas
Abstract in Portuguese
Mulheres asmáticas na pós-menopausa podem apresentar piora dos sintomas, portanto neste trabalho investigamos o papel dos hormônios sexuais femininos (HSF) sobre a inflamação alérgica pulmonar. A re-exposição ao antígeno exacerbou a inflamação alérgica pulmonar e a liberação de mediadores no pulmão dos animais alérgicos ovariectomizados (OVx). O valor da reatividade traqueal foi semelhante ao observado nos animais alérgicos Sham/OVx. O tratamento com estrógeno exacerbou a inflamação pulmonar, mas atenuou a reatividade das vias aéreas. O tratamento com progesterona não alterou o número de células do lavado broncoalveolar e atenuou a reatividade das vias aéreas, apesar acentuar a produção de muco e de colágeno. O tratamento com estrógeno em associação com a progesterona atenuou a inflamação pulmonar aos valores encontrados nos animais alérgicos Sham/OVx. Nossos estudos apontam para uma possível dissociação entre os efeitos moduladores dos HSF sobre a resposta inflamatória, notadamente no recrutamento celular e as alterações de mecânica respiratória.
Title in English
Evaluation of the role of female sex hormones in a murine model of experimental asthma.
Keywords in English
Airways reactivity
Asthma
Female sex hormones
Lung mechanics
Mice
Abstract in English
Asthmatic postmenopausal women may experience worsening of symptoms, so in this work we investigated the role of female sex hormones (HSF) on pulmonary allergic inflammation. The re-exposure to antigen exacerbated allergic lung inflammation and release of mediators in the lungs of ovariectomized allergic mice (OVX ) . The value of tracheal reactivity was similar to that observed in allergic Sham/OVx . Treatment with estrogen exacerbated pulmonary inflammation but attenuated airways reactivity. Treatment with progesterone did not alter the number of cells in bronchoalveolar lavage and attenuated airways reactivity, although enhance mucus production and collagen. Treatment with estrogen in combination with progesterone attenuated lung inflammation to the values found in allergic animals Sham/OVx. Our studies point to a possible dissociation between the modulatory effects of HSF on the inflammatory response, especially on cell recruitment and alterations in respiratory mechanic.
 
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Release Date
2016-12-15
Publishing Date
2014-12-16
 
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