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Master's Dissertation
DOI
10.11606/D.42.2013.tde-11062014-145521
Document
Author
Full name
Natália Mendes Schöwe
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2013
Supervisor
Committee
Viel, Tânia Araújo (President)
Avellar, Maria Christina Werneck de
Muscara, Marcelo Nicolas
Title in Portuguese
Relação entre o tratamento crônico com lítio e papel do sistema colinérgico na neuroinflamação.
Keywords in Portuguese
Camundongos
Inflamação
Lítio
Receptores colinérgicos
Abstract in Portuguese
É conhecido que o sistema colinérgico, via receptor nicotínico a7, atua como atenuador do processo inflamatório. O lítio é utilizado no tratamento do transtorno afetivo bipolar e, em microdoses, foi benéfico para o tratamento da doença de Alzheimer. O objetivo desse estudo foi avaliar os efeitos do tratamento crônico com microdoses de lítio para a formação de mediadores inflamatórios em cérebros de camundongos jovens, após injeção intraperitoneal de LPS, e se os receptores a7 estavam envolvidos nesse processo. Após sete meses de tratamento, foi observado que o grupo lítio-LPS apresentou formação da memória espacial, diferentemente do grupo água-LPS. Oito dias após a injeção de LPS, os níveis de IL-6, TNF-a, IL-10 e pGSK-3b/GSK-3b estavam iguais em todos os grupos, evidenciando que o processo inflamatório já estava terminado. Além disso, não houve diferença com relação à densidade de CAT e a7. Não foi possível comprovar ou excluir o efeito anti-inflamatório das microdoses de lítio. Portanto, o desenho experimental deverá ser ajustado.
Title in English
Relationship between the chronic treatment with lithium and the role of cholinergic system in neuroinflammation.
Keywords in English
Cholinergic receptors
Inflammation
Lithium
Mice
Abstract in English
It is known that the cholinergic system, via a7 nicotinic receptors, acts as attenuator of the inflammatory process. Lithium is used in the treatment of bipolar disorder and microdosing was beneficial for the treatment of Alzheimer's disease. The aim of this study was to evaluate the effects of chronic treatment with lithium microdoses for the formation of inflammatory mediators in the brain of young mice after intraperitoneal injection of LPS, and if a7 receptors were involved in this process. After seven months of treatment, animals treated with lithium-LPS presented spatial memory, while water-LPS animals did not. Eight days after the induction of acute inflammation levels of IL-6, TNF-a, IL-10 and pGSK-3b/GSK-3b were the same in all groups, indicating that the inflammatory process had been completed. Still, there was no difference with respect to the density of CAT and a7. It was not possible to confirm or exclude the anti-inflammatory effect of microdoses of lithium. So, the experimental design will be adjusted.
 
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Publishing Date
2014-06-17
 
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