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Master's Dissertation
DOI
Document
Author
Full name
Mariana Hayashi Garcia
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2017
Supervisor
Committee
Nunes, Anderson de Sá (President)
Carboni, Beatriz Simonsen Stolf
Fonseca, Denise Morais da
Gomes, Regis Bernardo Brandim
Title in Portuguese
Efeito dos componentes salivares de Aedes aegypti em infecções por parasitos do gênero Leishmania.
Keywords in Portuguese
Aedes aegypti
Leishmania (Leishmania) amazonensis
extrato de glândula salivar
imunomodulação
macrófagos
Abstract in Portuguese
Aedes aegypti é importante vetor de patógeno causador de doença como dengue, febre amarela, febre Chikungunya e Zika. A fêmea realiza repasto sanguíneo a fim de adquirir nutriente para o desenvolvimento dos ovos. Neste contexto, a saliva possui papel fundamental, representando o elo entre o artrópode hematófago, seu hospedeiro vertebrado e o potencial patógeno a ser transmitido. Nessa saliva encontra-se um coquetel farmacológico com diversas atividades biológicas, como a presença de peptídeos antimicrobianos e moléculas com funções imunomoduladoras sobre células do hospedeiro vertebrado, com especial atenção aos macrófagos. Como os macrófagos também estão envolvidos nos mecanismos efetores da resposta contra protozoários do gênero Leishmania e a leishmaniose apresenta-se como uma doença de caráter zoonótico de grande relevância em saúde pública, o objetivo deste trabalho foi de avaliar o efeito do extrato de glândula salivar (EGS) de A. aegypti em infecções por Leishmania. Nossos resultados mostraram aumento da infecção in vivo e in vitro na presença do EGS, sugerindo fortemente que o EGS de A. aegypti é capaz de aumentar a infecção por Leishmania.
Title in English
Effect of Aedes aegypti salivary components in the infection by parasites of Leishmania genus.
Keywords in English
Aedes aegypti
Leishmania (Leishmania) amazonensis
macrophage
salivary gland extract
Abstract in English
Aedes aegypti is an important vector of disease-causing pathogens such as dengue, yellow fever, Chikungunya and Zika fever. The mosquito female takes a blood meal in order to develop the eggs. In this context, a saliva plays a key role, representing the link between the hematophagous arthropod, its vertebrate host and the potential pathogen to be transmitted. During the evolutionary process, these insects developed a salivary cocktail with an arsenal of molecules presenting several immunomodulatory properties in host cells, such as macrophages. As macrophages are also involved in the mechanisms of response against protozoa of the genus Leishmania and leishmaniasis is a zoonotic disease of great relevance in public health, the aim of this work is to evaluate the effect of salivary gland extract (SGE) of A. aegypti in Leishmania infections. Our results showed increased infection, in vivo and in vitro, in the presence of SGE, strongly suggesting that A. aegypti EGS is able to increase infection by Leishmania.
 
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Release Date
2019-10-05
Publishing Date
2017-10-05
 
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