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Doctoral Thesis
DOI
10.11606/T.42.2007.tde-15012008-154514
Document
Author
Full name
Isabel Cristina Cespedes
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2007
Supervisor
Committee
Bittencourt, Jackson Cioni (President)
Palma, Mario Sergio
Rizzolo, Roelf Justino Cruz
Scavone, Cristoforo
Sita, Luciane Valéria
Title in Portuguese
Presença da proteína Fos em regiões do sistema nervoso central de roedores submetidos ou não ao Alprazolam após choque e restrição
Keywords in Portuguese
CRF
Estresse
Núcleo EW
Núcleo PVH
Sistema Nervoso Central
Ucn-I
Abstract in Portuguese
O CRF é um regulador do eixo HPA, gerando respostas neuroendócrinas, autônomicas, comportamentais ao estresse, assim como a Ucn-I. Os benzodiazepínicos agem por um efeito inibitório sobre o CRF e um efeito ainda discutido sobre a Ucn-I.Para análise das áreas relacionadas à resposta ao estresse pela imunorreatividade da proteína Fos, da expressão do mRNA do CRF e da Ucn-I, e dos efeitos do alprazolam, ratos foram submetidos aos estresses de restrição e eletrochoque, e ao alprazolam. No estresse de restrição as áreas com maior imunorreatividade da proteína Fos foram PVH e AMIme, e no estresse de eletrochoque foram AMIme e PAGdl. Com o alprazolam houve uma baixa imunorreatividade nas áreas PVH, PAGlat e CC no grupo restrição e, PVH, LSV e PAGlat no grupo choque, com alta imunorreatividade nas áreas EW e LSV no grupo restrição e PAGdl no grupo choque. O fármaco gerou uma diminuição da expressão do mRNA do CRF no PVH no grupo restrição e um aumento no grupo choque, e um aumento da expressão do mRNA da Ucn-I no EW no grupo restrição e uma diminuição no grupo choque.
Title in English
Immunoreactivity of Fos protein in the central nervous system of rats after restraint and footshock stress and the use of Alprazolan.
Keywords in English
Central Nervous System
CRF
EW
PVH
Stress
Ucn-I
Abstract in English
The CRF is a regulator of the HPA axis, with neuroendocrine, autonomic and behavioral responses to the stress, such as the Ucn-I. The benzodiazepines performing an inhibitory effect on the CRF and a possibly effect on the Ucn-I. It was analyzed the stress related areas by Fos protein and the expression of the CRF and Ucn- I mRNA. Rats were submitted to the restraint and electroshock stress, and to the alprazolan. The restraint stress showed greater Fos-ir in the following areas PVH and AMIme and AMIme and PAGdl in the the electroshock stress. The alprazolam had an inhibition effect in the following areas PVH, PAGlat and CC in the restraint group, and PVH, LSV and PAGlat in the electroshock group. The alprazolan had an excitatory effect in the following areas EW and LSV in the restraint group, and PAGdl in the electroshock group. The alprazolan caused reduction of CRF mRNA in the PVH in the restraint group and increase in the electroshock group, and increase of Ucn-I mRNA in the EW in the restraint group, with reduction in the electroshock group.
 
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Publishing Date
2008-01-15
 
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