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Master's Dissertation
DOI
10.11606/D.42.2011.tde-09022012-121522
Document
Author
Full name
Renata Juliana da Silva
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2011
Supervisor
Committee
Bittencourt, Jackson Cioni (President)
Castelucci, Patricia
D'Avila, Kátia de Angelis Lobo
Title in Portuguese
Efeitos do treinamento físico intenso e da restrição alimentar sobre a ação da leptina mediada pelo hormônio concentrador de melanina no eixo reprodutor de ratas.
Keywords in Portuguese
Ciclo estral animal
Desnutrição
Exercícios físico
Hormônio concentrador de melanina
Leptina
Neuroendocrinologia de animal
Abstract in Portuguese
Avaliamos o efeito do treinamento físico intenso e da restrição alimentar no eixo reprodutor e na expressão do RNAm do MCH em ratas fêmeas. Utilizamos ratas fêmeas sedentárias alimentadas (SA), sedentárias com restrição alimentar, treinadas alimentadas (TA) e treinadas com restrição alimentar. O grupo TR entrou em anestro a partir da quarta semana de experimento. Os grupos restritos apresentaram redução de peso corporal, ovários, úteros e tecido adiposo branco, comparados aos alimentados. Houve redução sérica de leptina nos grupos SR e TR. Os grupos TA, SR e TR apresentaram cistos ovarianos. A expressão do RNAm do ppMCH na área incerto-hipotalâmica (IHy) foi menor nos animais TR, SR e nos animais alimentados em proestro, e na área hipotalâmica lateral (LHA) foi maior nos animais em restrição alimentar e nos animais alimentados em proestro. Conclui-se que a leptina exerce forte influencia no eixo reprodutor feminino, tal ação parece ter envolvimento do MCH, sobretudo o proveniente da IHy, uma vez que o MCH da LHA tem relação com o estímulo a busca de alimento.
Title in English
Effects of intense physical training and food restriction on the action of leptin mediated by melanin concentrating hormone in the reproductive axis in female rats.
Keywords in English
Animal estrous cycle
Animal neuroendocrinology
Leptin
Malnutrition
Melanin-concentrating hormone
Physical exercise
Abstract in English
We evaluated the effect of intense physical training and food restriction on the reproductive axis and MCH mRNA expression in female rats. We used female rats fed sedentary (SF), food-restricted sedentary, trained fed (TF) and trained with food restriction. The group entered anestrus TR from the fourth week of the experiment. The restricted groups had reduced body weight, ovary, uterus and white adipose tissue, compared to the fed. There was a reduction of serum leptin in the SR and TR groups. The TF groups, SR and TR had ovarian cysts. The expression of mRNA ppMCH incerto-hypothalamic area (IHy) was lower in TR animals, SR and animals fed on proestrus, and the lateral hypothalamic area (LHA) were higher in animals on restricted food and animal feeding in proestrus. It is concluded that leptin exerts a strong influence on female reproductive axis, such action appears to have involvement of MCH, especially from the IHy, since the MCH of the LHA is related to the motivational behavior associated to the search for food.
 
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Publishing Date
2012-03-14
 
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