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Doctoral Thesis
DOI
10.11606/T.39.2010.tde-26102011-160209
Document
Author
Full name
Fernanda Roberta Roque Redondo
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Paulo, 2010
Supervisor
Committee
Oliveira, Edilamar Menezes de (President)
Carvalho, Maria Helena Catelli de
Negrão, Carlos Eduardo
Ramires, Paulo Rizzo
Sánchez, Mercedes Salaices
Title in Portuguese
Efeitos do treinamento físico aeróbio sobre as alterações vasculares estruturais, mecânicas e funcionais de ratos espontaneamente hipertensos: mecanismos implicados
Keywords in Portuguese
Alterações vasculares
Hipertensão arterial
Ratos espontaneamente hipertensos
Treinamento físico aeróbio
Abstract in Portuguese
A hipertensão arterial (HA) é um importante problema de saúde pública e representa um dos fatores de risco mais relevantes na etiologia das doenças cardiovasculares. O incremento na resistência vascular periférica (RVP) é a principal característica da HA e está diretamente associado a alterações vasculares estruturais, mecânicas e funcionais. O aumento do estresse oxidativo tem sido considerado um importante fator que contribui para o desenvolvimento e estabelecimento da HA. A prática regular de exercício físico aeróbio, utilizada como medida não farmacológica para o tratamento da HA, tem se mostrado efetiva em reduzir os valores de pressão arterial através da promoção de diversas adaptações cardiovasculares. Este estudo teve como objetivo avaliar os efeitos do treinamento físico (TF) aeróbio sobre as alterações vasculares de artérias coronárias e mesentéricas de resistência induzidas pela HA. Para isso ratos espontaneamente hipertensos (SHR) foram submetidos a um protocolo de TF aeróbio. Este TF promoveu alterações estruturais, avaliadas através de um miógrafo de pressão, como o remodelamento vascular em coronárias e redução de colágeno com aumento na área das fenestras da elastina em mesentéricas, as quais foram associadas com a melhora na rigidez vascular. Além disso, o TF induziu melhora da função endotelial, avaliada através de estudos de reatividade vascular, principalmente mediada por aumento na disponibilidade de óxido nítrico ocasionada por redução do estresse oxidativo. Os resultados sugerem que o TF promoveu alterações vasculares que podem contribuir para diminuir a RVP e reduzir a pressão arterial
Title in English
Effects of aerobic exercise trining on the vascular structural mechanical and functional alterations of spontaneously hipertensive rats: mechanisms involved
Keywords in English
Aerobic exercise training
Hypertension
Spontaneously hypertensive rats.
Vascular alterations
Abstract in English
Hypertension is a major public health problem and represents one of the most important risk factors in the etiology of cardiovascular diseases. Peripheral vascular resistance increased is the main feature of hypertension and it is directly associated with vascular structural, mechanical and functional alterations. Oxidative stress increased has been considered an important factor that contributes to the development and establishment of hypertension. Regular exercise training, used as a non pharmacological treatment of hypertension, has been effective reducing blood pressure by promoting several cardiovascular adaptations. The aim of the present study was evaluate the effects of treadmill training on the vascular alterations of coronary and mesenteric resistance arteries induced by hypertension. Then, spontaneously hypertensive rats (SHR) were submitted to an aerobic exercise training protocol. The exercise training promoted structural alterations, measured by a pressure myography, as coronary vascular remodeling and collagen reduction and also the area of fenestrae in the elastin of mesenteric arteries were increased, which were associated with vascular stiffness improvement. In addition, the exercise training improved the endothelial function in both arterial beds, as evaluated by vascular reactivity analysis, mediated primarily by increasing nitric oxide availability caused by oxidative stress reduction. The results suggest that exercise training promoted vascular changes that can contribute to reduce peripheral vascular resistance and blood pressure
 
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1CAPA.pdf (7.88 Kbytes)
2FOLHADEROSTO.pdf (7.91 Kbytes)
3AGRADECIMENTOS.pdf (36.76 Kbytes)
4SUMARIO.pdf (156.10 Kbytes)
5aListadeTabelas.pdf (12.49 Kbytes)
5bListadeFiguras.pdf (51.95 Kbytes)
5cListadeSiglas.pdf (78.69 Kbytes)
6RESUMO.pdf (9.94 Kbytes)
7ABSTRACT.pdf (9.41 Kbytes)
8TESEversaofinal.pdf (1.99 Mbytes)
FICHAcatalografica.doc (30.00 Kbytes)
Publishing Date
2011-10-27
 
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