• JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
 
  Bookmark and Share
 
 
Master's Dissertation
DOI
https://doi.org/10.11606/D.17.2020.tde-23082020-151418
Document
Author
Full name
Thaisa Gvozdenovic Medina Bricio
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
Ribeirão Preto, 2020
Supervisor
Committee
Muglia, Valdair Francisco (President)
Macedo, Tulio Augusto Alves
Tucci Junior, Silvio
Title in Portuguese
Validação do escore VI-RADS para estadiamento das neoplasias vesicais
Keywords in Portuguese
Camada muscular
Neoplasia vesical
Ressonância magnética
VI-RADS
Abstract in Portuguese
Objetivo: Proceder a uma validação externa da normativa VI-RADS, analisando a acurácia diagnóstica, comparando os escores das imagens em T2, difusão, contraste dinâmico (DCE) e VI-RADS final, além de verificar a concordância interobservador entre radiologistas de diversos níveis de experiência. Materiais e métodos: Foram avaliados estudos de ressonância magnética de pacientes com a suspeita clínica de neoplasia vesical entre junho de 2017 e janeiro de 2020 anteriormente a ressecção transuretral (RTU) retrospectivamente em um único centro. Todas as RM foram analisadas por três radiologistas com níveis de experiência diferentes, que atribuíram um escore VI-RADS para cada lesão em cada sequencia de RM. Foram calculados então a partir dessas análises sensibilidade, especificidade, valor preditivo positivo (VPP), valor preditivo negativo (VPN), acurácia diagnóstica e concordância interobservador. Resultados: Analisando o escore VI-RADS final atribuído por cada observador, a sensibilidade, foi de 94,1%, com intervalo de confiança de 95%, variando de 71,3 a 99,8% para o observador 1, 76,5% (50,1-93,2%) para o observador 2 e 94,1% (71,3-99,8%) para o observador 3, com uma especificidade, respectivamente, de 54,5% (32,2-75,6), 81,8% (59,7-94,8%) e 77,3% (54,6-92,1%). O VPP foi de 61,5% (49,9 - 72,0%) para o observador 1, 76,5% (56,3-89,1%) para as análises do observador 2 e 76,2% (59,5- 87,5%) para o observador 3, com um VPN de 92,3% (63,3-98,8%) para o observador 1, 81,8% (65,1 - 91,6%) para o observador 2 e 94,4% (71,5-99,1%) para o observador 3. A acurácia obtida foi de 71,8% (55,1-81,0%) para o observador 1, 79,5% (63,5- 90,7%) para o observador 2 e 84,6% (69,5-94,1%) para o observador 3. Conclusão: A normativa VI-RADS demonstrou boa acurácia para avaliação da invasão da camada muscular vesical nos tumores de bexiga, concordante com a literatura disponível. O nível de reprodutibilidade foi bom, apesar de discretamente inferior aos mencionados na literatura.
Title in English
Validations of the VI-RADS scoring system for vesical neoplasm
Keywords in English
MRI
Muscle layer
Vesical neoplasm
VI-RADS
Abstract in English
Objectives: The main purpose of this study was to validate the VI-RADS scoring system for vesical neoplasms, using accuracy as a marker by comparing the categories given by each radiologist for each MRI sequencies (T2, DWI, DCE and final VI-RADS escore) with the pathological findings. Besides the main goal, we assessed the interobserver agreement in different levels of experience. Materials and Methods: This was a retrospective study, in a single center where the MRI studies between june 2017 and february 2020 of patients with the clinical suspition of vesical neoplasm were analysed before they undergo any kind of intervention. Each MRI study was analysed by three different radiologists with different levels of experience, who categorized the lesions as set in the VI-RADS coring system in each MRI sequence. After that sensitivity, specificity, positive predictive value, negative predictive value, accuracy and interobserver agreement were then calculated. Results: By analysing the scores given by each radiologist for each vesical tumor we obtained sensitivy of 94,1%, with confidence interval of 95%, varying from 71,3 to 99,8% for observer 1, 76,5% (50,1-93,2%) for observer 2 and 94,1% (71,3-99,8%) for oberverser 3. The specificity was, respectively, 54,5% (32,2-75,6), 81,8% (59,7-94,8%) and 77,3% (54,6-92,1%). THE PPV was 61,5% (49,9 - 72,0%) for observer 1, 76,5% (56,3-89,1%) for observer 2 and 76,2% (59,5-87,5%) for observer 3, with a NPV 92,3% (63,3-98,8%) for observer 1, 81,8% (65,1 - 91,6%) for observer 2 and 94,4% (71,5-99,1%) for observer 3. Accuracy was 71,8% (55,1- 81,0%) for observer 1, 79,5% (63,5-90,7%) for observer 2 and 84,6% (69,5-94,1%) for observer 3. Conclusion: The scoring system VI-RADS is accurate in demonstrating muscle invasive bladder neoplasm, in agreement with the recent literature. The level of reproducibility as good, but slightly inferior than mencioned in literature.
 
WARNING - Viewing this document is conditioned on your acceptance of the following terms of use:
This document is only for private use for research and teaching activities. Reproduction for commercial use is forbidden. This rights cover the whole data about this document as well as its contents. Any uses or copies of this document in whole or in part must include the author's name.
Publishing Date
2020-10-19
 
WARNING: Learn what derived works are clicking here.
All rights of the thesis/dissertation are from the authors
CeTI-SC/STI
Digital Library of Theses and Dissertations of USP. Copyright © 2001-2022. All rights reserved.