• JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
 
  Bookmark and Share
 
 
Master's Dissertation
DOI
10.11606/D.17.2017.tde-06012017-161021
Document
Author
Full name
Suzana Eggers Turra
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
Ribeirão Preto, 2016
Supervisor
Committee
Cavalli, Ricardo de Carvalho (President)
Pacagnella, Rodolfo de Carvalho
Quintana, Silvana Maria
Title in Portuguese
Citocinas séricas em gestantes no segundo trimestre e relação com partos pré-termo em coortes de duas cidades brasileiras
Keywords in Portuguese
Citocinas séricas
coortes de pré-natal
parto pré-termo
Abstract in Portuguese
Objetivo: avaliar a associação dos níveis séricos de citocinas em gestantes assintomáticas no segundo trimestre e nascimentos pré-termo (NPT). Pacientes e métodos: Estudo caso-controle aninhado a uma coorte de conveniência prospectiva. Foram incluídas gestantes de feto único entre 20 e 25 semanas e 6 dias de idade gestacional de 2 cidades brasileiras, as quais foram submetidas a entrevista e coleta de amostras de sangue venoso e avaliadas por entrevista no momento do nascimento. Dos NPT, 197 foram consideradas como grupo de casos e o grupo controle foi selecionado por sorteio, totalizando 426 pacientes no grupo controle. Foram avaliadas 41 citocinas séricas e comparadas entre os grupos. Resultados: Na primeira análise, as citocinas GRO, PDGF-BB e sCD40L mostraram níveis séricos diminuídos no grupo dos partos pré-termo (PPT) (p<0,05). Analisando apenas os PPT espontâneos, as citocinas GRO, sCD40L e MCP-1 apresentaram níveis diminuídos no grupo de casos (p<0,05). As citocinas que apresentaram níveis séricos com valores discrepantes foram submetidas a uma transformação logarítmica para posterior comparação entre os grupos de casos e controles. No grupo de casos incluindo apenas PPT espontâneos, verificou-se níveis aumentados de IL-2 (p<0,05). Foi significativo entre os grupos caso e controle a incidência de tabagismo materno e histórico de parto pré-termo anterior, sendo então essas características consideradas como fatores de risco nas análises multivariadas das citocinas dosadas. Apenas GRO demonstrou diferença em suas concentrações séricas entre grupos caso e controle na análise multivariada. Conclusão: Níveis séricos menores de GRO no segundo trimestre estão associados a maior risco de prematuridade, podendo refletir uma deficiência na resposta inflamatória materna.
Title in English
Serum cytokine levels in second trimester pregnancy and relation with preterm birth in a cohort in two brazilian cities
Keywords in English
prenatal cohort
preterm birth
Serum cytokines
Abstract in English
Objective: To evaluate the association between second trimester serum cytokine levels in asymptomatic pregnant women and preterm births (PTB). Patientes and methods: Cohort-nested case-control study including singleton pregnant women between 20 and 25 weeks and 6 days of gestation in two Brazilian cities. The patients were interviewed and collection of venous blood samples was performed. They were again interviewed at time of birth. Among PTB, 197 were considered as case group. The control group was selected among term births (426 patients). Fourty-one cytokines were compared between groups. Results: Cytokines GRO, PDGF-BB and sCD40L showed decreased serum levels in PTB group (p<0.05). When analyzing only spontaneous PTB, GRO, sCD40L and MCP-1 levels showed decreased levels in the case group (p <0.05). A logarithmic transformation was performed among cytokines with discrepant serum levels in an attempt of verifying the outliers influency, and it has shown increased levels of IL-2 in the group of spontaneous preterm delivery (p <0.05). In both analyzes, the incidence of maternal smoking and history of previous preterm delivery was significantly different between case and control groups. In multivariate analysis, only GRO demonstrated different serum levels between case and control groups. Conclusion: Lower second trimester serum levels of GRO in assymptomatic women are associated with increased number of preterm births. This finding may reflect a deficiency in maternal inflammatory response.
 
WARNING - Viewing this document is conditioned on your acceptance of the following terms of use:
This document is only for private use for research and teaching activities. Reproduction for commercial use is forbidden. This rights cover the whole data about this document as well as its contents. Any uses or copies of this document in whole or in part must include the author's name.
Publishing Date
2017-02-15
 
WARNING: Learn what derived works are clicking here.
All rights of the thesis/dissertation are from the authors
CeTI-SC/STI
Digital Library of Theses and Dissertations of USP. Copyright © 2001-2021. All rights reserved.