• JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
  • JoomlaWorks Simple Image Rotator
 
  Bookmark and Share
 
 
Doctoral Thesis
DOI
https://doi.org/10.11606/T.17.2022.tde-30092022-091143
Document
Author
Full name
Wagner Moneda Telini
Institute/School/College
Knowledge Area
Date of Defense
Published
Ribeirão Preto, 2021
Supervisor
Committee
Fabro, Alexandre Todorovic (President)
Cetlin, Andrea de Cassia Vernier Antunes
Chahud, Fernando
Storrer, Karin Mueller
Title in Portuguese
Perfil das células dendríticas pulmonares como potencial biomarcador de pneumonite de hipersensibilidade: estudo translacional e multidisciplinar
Keywords in Portuguese
Biopsia pulmonar cirúrgica
Célula dendrítica
Doença pulmonar intersticial
Fibrose
Função pulmonar
Imunohistoquímica
Pneumonite de hipersensibilidade
Sobrevida
Tomografia computadorizada do tórax
Abstract in Portuguese
A pneumonite de hipersensibilidade é prevalente entre as doenças pulmonares intersticiais sendo desencadeada por reações de hipersensibilidade dos tipos III e IV em resposta à inalação de agentes ambientais diversos, com a formação de granulomas e, por vezes, fibrose pulmonar. Padrões específicos de resposta linfocitária estão relacionados às formas crônicas da doença e acredita-se haver relação da sua evolução com o perfil de imunoexpressão das células dendríticas do tecido respiratório, sua interação com outras células apresentadoras de antígenos e, por fim, sua influência na diferenciação e expressão das linhagens linfocitárias envolvidas com as reações de hipersensibilidade. Através de imunohistoquímica e técnicas translacionais, esta pesquisa evidenciou fenótipos de expressão imunológica das células dendríticas epiteliais e intersticiais pulmonares na pneumonite de hipersensibilidade correlacionando-os com o microambiente inflamatório desta doença pulmonar intersticial, seus padrões histopatológicos, radiológicos, funcionais e formas clínicas. Por fim, padrões de expressão imunofenotípica das células dendríticas foram correlacionados com a sobrevida dos participantes da pesquisa com pneumonite de hipersensibilidade e controles.
Title in English
Lung dendritic cell profile as a potential biomarker of hypersensitivity pneumonitis: translational and multidisciplinary study
Keywords in English
Chest computed tomography
Dendritic cell
Fibrosis
Hypersensitivity pneumonitis
Immunohistochemistry
Interstitial lung disease
Lung function
Surgical lung biopsy
Survival
Abstract in English
Hypersensitivity pneumonitis is prevalent among interstitial lung diseases and is triggered by type III and IV hypersensitivity reactions in response to the inhalation of various environmental agents, with the formation of granulomas and, sometimes, pulmonary fibrosis. Specific patterns of lymphocyte response are related to chronic forms of the disease and its evolution is believed to be related to the immunoexpression profile of dendritic cells of the respiratory tissue, its interaction with other antigen-presenting cells and, finally, its influence on differentiation and expression of lymphocytic lineages involved as hypersensitivity reactions. Through immunohistochemistry and translational techniques, this research proposes immunological expression phenotypes of epithelial and interstitial lung dendritic cells in hypersensitivity pneumonitis, correlating them with the inflammatory microenvironment of this interstitial lung disease, its histopathological, radiological, functional patterns and clinical presentations. Finally, immunophenotypic expression patterns of dendritic cells are correlated with the survival of research participants with hypersensitivity pneumonitis and controls.
 
WARNING - Viewing this document is conditioned on your acceptance of the following terms of use:
This document is only for private use for research and teaching activities. Reproduction for commercial use is forbidden. This rights cover the whole data about this document as well as its contents. Any uses or copies of this document in whole or in part must include the author's name.
WAGNERfinal.pdf (4.13 Mbytes)
WAGNERresumo.pdf (266.71 Kbytes)
Publishing Date
2022-11-03
 
WARNING: Learn what derived works are clicking here.
All rights of the thesis/dissertation are from the authors
CeTI-SC/STI
Digital Library of Theses and Dissertations of USP. Copyright © 2001-2024. All rights reserved.