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Master's Dissertation
DOI
https://doi.org/10.11606/D.17.2001.tde-27022024-104700
Document
Author
Full name
Eduardo Andery Abbud
Institute/School/College
Knowledge Area
Date of Defense
Published
Ribeirão Preto, 2001
Supervisor
Committee
Trad, Clovis Simao (President)
Bellucci, Angela Delete
Ramos, Simone Gusmão
Title in Portuguese
Formas de apresentação da pneumonia em organização criptogênica na tomografia computadorizada de alta resolução
Keywords in Portuguese
BOOP
Bronquiolite obliterante com pneumonia em organização
Pneumonia em organização criptogênica
POC
Tomografia computadorizada de alta resolução
Abstract in Portuguese
Foram analisados, retrospectivamente, os resultados das tomografias computadorizadas de alta resolução de 18 pacientes submetidos à biópsia pulmonar a céu aberto, com o diagnóstico de pneumonia em organização criptogênica. Duas avaliações do exame anatomopatológico foram realizadas: a primeira feita por patologistas gerais de diversos laboratórios e a segunda por um único patologista, especializado em patologia intersticial pulmonar. Foram selecionados apenas casos em que houve concordância entre ambos, tendo sido excluídos do grupo aqueles pacientes com evidências clínicas ou laboratoriais de eosinofilia, doenças intersticiais pulmonares, doenças ocupacionais, síndrome de imunodeficiência adquirida, doenças do colágeno, neoplasias primárias ou secundárias e doenças granulomatosas. Foram encontradas quatro formas de apresentação da pneumonia em organização criptogênica: consolidação peribrônquica, consolidação panlobular, nódulos e massas pulmonares. As consolidações peribrônquicas apresentavam imagem de formato triangular, broncograma aéreo, localização córtico-medular e o maior eixo da lesão axial. As consolidações panlobulares apresentavam localização cortical, formato em "lâmina" ou "arco", o maior eixo da lesão com alinhamento subpleural; a interface com o interstício subpleural presente ou não. Foram considerados nódulos estruturas de formato arredondado ou ovalado e diâmetro menor que 3,0 cm, contornos irregulares, com ou sem radiotransparências no seu interior. As formações nodulares, com diâmetro maior que 3,0 cm, foram denominadas de massa pulmonar. As formas de apresentação foram agrupadas em dois padrões, consolidação pulmonar e massa pulmonar. O padrão de consolidação pulmonar englobou as consolidações peribrônquicas e panlobulares associadas ou não a nódulos pulmonares. O padrão de massa pulmonar possuía a forma de apresentação de massa pulmonar isolada ou associada às demais. A diferenciação do padrão de massa pulmonar justifica-se, em razão de que, faz diagnóstico diferencial com neoplasias. Com relação à localização, na série estudada, não houve preponderância entre as localizações cortical e córtico-medular; entretanto, não houve lesão medular isolada. Os padrões, assim como as formas de apresentação não são necessariamente exclusivos, já que representam o mesmo achado anatomopatológico.
Title in English
Presentation forms of cryptogenic organizing pneumonia on high-resolution computed tomography
Keywords in English
BOOP
Bronchiolitis obliterans with organizing pneumonia
Cryptogenic organizing pneumonia
High-resolution computed tomography
POC
Abstract in English
A retrospective analysis was conducted on the results of high resolution computer tomographies of 18 patients submitted to open surgery for a pulmonary biopsy, with a diagnosis of cryptogenic organizing pneumonia. The anatomopathological exams were submitted to two evaluations: one made by general pathologists from different laboratories and the other by a single pathologist specialized in interstitial pulmonary disease. Only cases in which there was agreement between the two evaluations were selected, and patients with clinical or laboratory evidence of eosinophilia, pulmonary interstitial disease, occupational diseases, acquired immunodeficiency syndrome, collagen diseases, primary or secondary neoplasias, and granulomatous diseases were excluded. Four forms of presentation of cryptogenic organizing pneumonia were detected: peribronchial consolidation, panlobular consolidation, pulmonary nodules and masses. The peribronchial consolidations presented images of triangular shape, an aerial bronchogram, cortico-medullary localization, and the widest axis of the lesion as an axial one. The panlobular consolidations were of cortical localization, shaped as a "lamina" or "arch", and their widest axis showed subpleural alignment; the interface with the subpleural interstitium was present or absent. Structures of rounded or oval shape with a diameter of less than 3.0 cm and irregular contours, containing radiotransparencies or not, were defined as nodules. Nodular formations with a diameter of more than 3.0 cm were defined as pulmonary masses. The forms of presentation were divided into two patterns: pulmonary consolidation and pulmonary mass. The pulmonary consolidation pattern included peribronchial and panlobular consolidations associated or not with pulmonary nodules. The pulmonary mass pattern consisted of the form of presentation of a separate pulmonary mass or a mass associated with all the others. The differentiation of the pulmonary mass patterns is justified, by the fact that, it makes differential diagnosis with neoplasia. There was no preponderance of the cortical or cortico-medullary localization, but no isolated medullary lesion was detected. The patterns as well as the forms of presentation are not necessarily exclusive since they represent the same anatomopathologic finding.
 
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