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Master's Dissertation
DOI
https://doi.org/10.11606/D.104.2022.tde-02012023-124537
Document
Author
Full name
Caroline Amantéa Stella
E-mail
Institute/School/College
Knowledge Area
Date of Defense
Published
São Carlos, 2022
Supervisor
Committee
Suzuki, Adriano Kamimura (President)
Perdoná, Gleici da Silva Castro
Silva, Giovana Oliveira
Title in Portuguese
Um estudo dos modelos de sobrevivência de longa duração LIGcr e GEPGWcr
Keywords in Portuguese
Análise de sobrevivência
Fração de cura
Modelo geometric exponentiated power generalized Weibull
Modelo logarítmico inversa Gaussiana
Simulação
Abstract in Portuguese
Neste trabalho estudamos dois modelos de sobrevivência de longa-duração denominados modelo Logarítmico Inversa Gaussiana com fração de cura (LIGcr) e modelo Geometric Exponentiated Power Generalized Weibull com fração de cura (GEPGWcr). Ambos os modelos levam em consideração a existência de heterogeneidade não observada. Para isso, os dois modelo consideram a variável aleatória que representa a fragilidade sendo discreta e começando em zero. Para os dois modelos estudados, os parâmetros são estimados pelo método de Máxima Verossimilhança. Em um estudo de simulação, investigamos as médias das estimativas, os vieses, os erros quadráticos médios e as probabilidades de cobertura. Por fim, mostramos a aplicabilidade dos modelos a conjuntos de dados reais.
Title in English
A study of LIGcr and GEPGWcr long-term survival models
Keywords in English
Cure fraction
Geometric exponentiated power generalized Weibull model
Logaritmic inverse Gaussian model
Simulation
Survival analysis
Abstract in English
In this work we study two long-term survival models denomined Logaritmic Inverse Gaussian cure rate (LIGcr) model and Geometric Exponentiated Power Generalized Weibull cure rate (GEPGWcr) model. Both models take into account the existence of unobserved heterogeneity. For this, both models consider a random variable that describes the frailty been discret and starting on zero. For both models studied, the parameters are estimated by the maximum likehood method. In a simulations study, we investigated the averages of the estimates, the biases, the mean squared errors and coverage probabilities. Finally, we show the applicability of the models to real data sets.
 
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Publishing Date
2023-01-02
 
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